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- W1569391229 abstract "This chapter discusses the presurgical evaluation of the patients with focal malformations due to abnormal cortical development (MCD). The methods used to confirm the diagnosis of epilepsy in focal MCD and those used to identify the epileptogenic lesion is briefly discussed. The role of subdural electrodes in the localization of the “epileptogenic zone” and the mapping of the functional cortex and its relationships with the anatomic (histopathological) lesion, and the epileptogenic zone is also discussed. MCD is a large group of histopathological cortical malformations with distinct architectural/cellular abnormalities, various MRI characteristics with variable degrees of in situ epileptogenicity and functional representation. The presurgical management of these malformations is complicated by the lack of a noninvasive technique that is able to identify the anatomical borders of the histopathological abnormality, define the location and extent of epileptogenicity, and correlate it with the functional representation. Further improvements in cellular and molecular imaging of clear markers of epileptogenicity, allow a clear definition of epileptogenicity and function; invasive evaluation is needed in some cases of focal MCD arising from potentially eloquent cortex." @default.
- W1569391229 created "2016-06-24" @default.
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- W1569391229 date "2003-01-01" @default.
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- W1569391229 title "Presurgical evaluation of patients with focal malformations due to abnormal cortical development (MCD)" @default.
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- W1569391229 doi "https://doi.org/10.1016/s1567-4231(03)03030-2" @default.
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