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- W1569395199 abstract "Identification of a sensitive diagnostic marker to differentiate primary hepatocellular carcinoma (HCC) from metastatic cancers to the liver is of immense clinical significance in the management of HCC. Diagnostic markers such as alpha-fetoprotein, HepPar1, and glypican-3 are available, but can suffer from poor specificity or lack of sensitivity. A rabbit polyclonal arginase-1 (ARG-1) has been identified as a sensitive and specific marker for HCC. Recently, a new rabbit monoclonal ARG-1 has also been developed; however it has not been tested directly against the referenced rabbit polyclonal ARG-2. Hepatocellular carcinoma and various normal and neoplastic tissues were evaluated by immunohistochemistry for specificity and sensitivity using rabbit monoclonal ARG-1. Additionally, a comparison study with the rabbit polyclonal and rabbit monoclonal ARG-1 was evaluated in normal tissues and in HCC. The result showed both ARG-1 antibodies stained normal kidney, liver, and pancreas. All other normal tissues were ..." @default.
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- W1569395199 date "2015-10-02" @default.
- W1569395199 modified "2023-09-23" @default.
- W1569395199 title "A novel rabbit monoclonal antibody arginase-1 is highly specific and highly sensitive in hepatocellular carcinoma" @default.
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- W1569395199 doi "https://doi.org/10.1179/2046023615y.0000000010" @default.
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