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• W1569396635 endingPage "12" @default.
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• W1569396635 abstract "Vitamin A has both positive and negative regulatory functions in the immune system. While vitamin A is required for normal formation of immune cells and epithelial cell barriers, vitamin A deficiency can lead to increased inflammatory responses and tissue damage. The mechanism with which vitamin A and its metabolites such as retinoids negatively regulate inflammatory responses has not been clearly defined. Recently, it has been established that retinoids promote the generation of immune-suppressive FoxP<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mn>3</mml:mn><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>regulatory T cells while they suppress the T cell differentiation into inflammatory Th17 cells in the periphery such as intestine. These novel functions of retinoids provide a potentially important immune regulatory mechanism. In this review, we discuss the functions of retinoids in the development of the FoxP<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mn>3</mml:mn><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>cells and Th17 cells, the phenotype and functions of retinoid-induced FoxP<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mn>3</mml:mn><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>T cells, and the impact of retinoid-induced FoxP<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mn>3</mml:mn><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>T cells on the immune tolerance." @default.
• W1569396635 created "2016-06-24" @default.
• W1569396635 creator A5084743693 @default.
• W1569396635 date "2008-01-01" @default.
• W1569396635 modified "2023-10-11" @default.
• W1569396635 title "Regulation of FoxP<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML><mml:mrow><mml:msup><mml:mn>3</mml:mn><mml:mo>+</mml:mo></mml:msup></mml:mrow></mml:math>Regulatory T Cells and Th17 Cells by Retinoids" @default.
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