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- W1569404236 abstract "In the past years, the attention of scientists has focused mainly on the study of the genetic information and alterations that regulate eukaryotic cell proliferation and that lead to neoplastic transformation. All therapeutic strategies against cancer are, to date, directed at DNA either with cytotoxic drugs or gene therapy. Little or no interest has been aroused by protein synthesis mechanisms. However, an increasing body of data is emerging about the involvement of translational processes and factors in control of cell proliferation, indicating that protein synthesis can be an additional target for anticancer strategies. In this paper we review the novel insights on the biochemical and molecular events leading to protein biosynthesis and we describe their involvement in cell proliferation and tumorigenesis. A possible mechanistic explanation is given by the interactions that occur between protein synthesis machinery and the proliferative signal transduction pathways and that are therefore suitable targets for indirect modulation of protein synthesis. We briefly describe the molecular tools used to block protein synthesis and the attempts made at increasing their efficacy. Finally, we propose a new multimodal strategy against cancer based on the simultaneous intervention on protein synthesis and signal transduction." @default.
- W1569404236 created "2016-06-24" @default.
- W1569404236 creator A5000930768 @default.
- W1569404236 creator A5035710316 @default.
- W1569404236 creator A5059323960 @default.
- W1569404236 creator A5073891277 @default.
- W1569404236 creator A5079443706 @default.
- W1569404236 creator A5087255163 @default.
- W1569404236 date "2000-07-01" @default.
- W1569404236 modified "2023-09-29" @default.
- W1569404236 title "Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation" @default.
- W1569404236 cites W105324358 @default.
- W1569404236 cites W141764926 @default.
- W1569404236 cites W145820509 @default.
- W1569404236 cites W1482431053 @default.
- W1569404236 cites W1484412481 @default.
- W1569404236 cites W1490663175 @default.
- W1569404236 cites W1490814033 @default.
- W1569404236 cites W1492914770 @default.
- W1569404236 cites W1494856196 @default.
- W1569404236 cites W1505080216 @default.
- W1569404236 cites W1521738036 @default.
- W1569404236 cites W152630325 @default.
- W1569404236 cites W1529554110 @default.
- W1569404236 cites W1531103802 @default.
- W1569404236 cites W1542603018 @default.
- W1569404236 cites W1544786964 @default.
- W1569404236 cites W1546570611 @default.
- W1569404236 cites W1559922183 @default.
- W1569404236 cites W1560827962 @default.
- W1569404236 cites W1564279867 @default.
- W1569404236 cites W1564741789 @default.
- W1569404236 cites W1569531441 @default.
- W1569404236 cites W1571012244 @default.
- W1569404236 cites W1583128395 @default.
- W1569404236 cites W1583592656 @default.
- W1569404236 cites W1585431151 @default.
- W1569404236 cites W1586747665 @default.
- W1569404236 cites W1587044218 @default.
- W1569404236 cites W1599457550 @default.
- W1569404236 cites W1602413288 @default.
- W1569404236 cites W1604872463 @default.
- W1569404236 cites W1606922327 @default.
- W1569404236 cites W1628030597 @default.
- W1569404236 cites W1647232102 @default.
- W1569404236 cites W1649136725 @default.
- W1569404236 cites W165613744 @default.
- W1569404236 cites W1663556064 @default.
- W1569404236 cites W1773230061 @default.
- W1569404236 cites W1810161475 @default.
- W1569404236 cites W1848207228 @default.
- W1569404236 cites W1873254229 @default.
- W1569404236 cites W1909400967 @default.
- W1569404236 cites W1912337284 @default.
- W1569404236 cites W1923815232 @default.
- W1569404236 cites W1964489808 @default.
- W1569404236 cites W1965772972 @default.
- W1569404236 cites W1966256682 @default.
- W1569404236 cites W1967520902 @default.
- W1569404236 cites W1967789322 @default.
- W1569404236 cites W1968523385 @default.
- W1569404236 cites W1970590543 @default.
- W1569404236 cites W1970812281 @default.
- W1569404236 cites W1970955548 @default.
- W1569404236 cites W1971405891 @default.
- W1569404236 cites W1973505995 @default.
- W1569404236 cites W1974262889 @default.
- W1569404236 cites W1974770298 @default.
- W1569404236 cites W1977012852 @default.
- W1569404236 cites W1981945864 @default.
- W1569404236 cites W1982645388 @default.
- W1569404236 cites W1985712154 @default.
- W1569404236 cites W1987105275 @default.
- W1569404236 cites W1987768768 @default.
- W1569404236 cites W1988609227 @default.
- W1569404236 cites W1991333097 @default.
- W1569404236 cites W1992401642 @default.
- W1569404236 cites W1993801915 @default.
- W1569404236 cites W1995819749 @default.
- W1569404236 cites W1996706809 @default.
- W1569404236 cites W1998084304 @default.
- W1569404236 cites W1998334193 @default.
- W1569404236 cites W2002541809 @default.
- W1569404236 cites W2003008394 @default.
- W1569404236 cites W2003804309 @default.
- W1569404236 cites W2003879700 @default.
- W1569404236 cites W2003935158 @default.
- W1569404236 cites W2004916618 @default.
- W1569404236 cites W2006020742 @default.
- W1569404236 cites W2006239014 @default.
- W1569404236 cites W2008082884 @default.
- W1569404236 cites W2010217335 @default.
- W1569404236 cites W2014272469 @default.
- W1569404236 cites W2016225291 @default.
- W1569404236 cites W2016476525 @default.
- W1569404236 cites W2017681450 @default.
- W1569404236 cites W2018221682 @default.
- W1569404236 cites W2019016164 @default.