Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569416291> ?p ?o ?g. }
- W1569416291 endingPage "2198" @default.
- W1569416291 startingPage "2191" @default.
- W1569416291 abstract "The present study examined the effect of the overexpression of early growth response gene (Egr-1) on transforming growth factor β-1 (TGF-β1) and p14ARF levels, in PC-3 and LNCaP prostate carcinoma cell lines. Amplification of EGR-1, TGF-β1 and p14ARF were observed in the two cell lines treated with different stimuli and resulted in a corresponding mRNA and protein expression. The downregulation of TGF-β1 and the attenuation of p14ARF expression by siRNA against Egr-1 predominantly suggested that TGF-β1 and p14ARF may be regulated by the transcription factor EGR-1. A marginal attenuation of cell growth in PC-3 and LNCaP prostate carcinoma cell lines overexpressing p14ARF was observed. Cells transfected with Egr-1 wild-type were able to grow and avoid cell cycle arrest and apoptosis in the presence or absence of p14ARF. In addition, EGR-1 stimulated the expression of TGF β-l as well as the accumulation of the p14ARF proteins. The results suggested that TGF-β1 and p14ARF activities in the presence of EGR-1 overexpression can exist independently of the presence of cells carrying a mutant p53 (PC-3 cells) or cells carrying a wild‑type p53 (LNCaP cells). Thus, the effect of EGR-1 on the growth of prostate carcinoma cells may occur through multiple mechanisms, but be independent of p53 expression control." @default.
- W1569416291 created "2016-06-24" @default.
- W1569416291 creator A5007509900 @default.
- W1569416291 creator A5023476792 @default.
- W1569416291 creator A5091136022 @default.
- W1569416291 date "2014-09-09" @default.
- W1569416291 modified "2023-10-16" @default.
- W1569416291 title "Association of increased levels of TGF-β1 and p14ARF in prostate carcinoma cell lines overexpressing Egr-1" @default.
- W1569416291 cites W1970999822 @default.
- W1569416291 cites W1973886069 @default.
- W1569416291 cites W1977439384 @default.
- W1569416291 cites W1981432908 @default.
- W1569416291 cites W1983434934 @default.
- W1569416291 cites W1985038223 @default.
- W1569416291 cites W1985274333 @default.
- W1569416291 cites W1986100686 @default.
- W1569416291 cites W1994026478 @default.
- W1569416291 cites W1996159020 @default.
- W1569416291 cites W1996834340 @default.
- W1569416291 cites W2003448771 @default.
- W1569416291 cites W2009395435 @default.
- W1569416291 cites W2040618680 @default.
- W1569416291 cites W2047064684 @default.
- W1569416291 cites W2050345976 @default.
- W1569416291 cites W2053502484 @default.
- W1569416291 cites W2056530510 @default.
- W1569416291 cites W2058296112 @default.
- W1569416291 cites W2060989729 @default.
- W1569416291 cites W2064566876 @default.
- W1569416291 cites W2075246605 @default.
- W1569416291 cites W2075514051 @default.
- W1569416291 cites W2082979850 @default.
- W1569416291 cites W2090585013 @default.
- W1569416291 cites W2092824717 @default.
- W1569416291 cites W2098643301 @default.
- W1569416291 cites W2103380615 @default.
- W1569416291 cites W2103616303 @default.
- W1569416291 cites W2114154263 @default.
- W1569416291 cites W2129379081 @default.
- W1569416291 cites W2141529421 @default.
- W1569416291 cites W2144251330 @default.
- W1569416291 cites W2160772200 @default.
- W1569416291 cites W2166866221 @default.
- W1569416291 doi "https://doi.org/10.3892/or.2014.3472" @default.
- W1569416291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25224321" @default.
- W1569416291 hasPublicationYear "2014" @default.
- W1569416291 type Work @default.
- W1569416291 sameAs 1569416291 @default.
- W1569416291 citedByCount "5" @default.
- W1569416291 countsByYear W15694162912018 @default.
- W1569416291 countsByYear W15694162912021 @default.
- W1569416291 countsByYear W15694162912023 @default.
- W1569416291 crossrefType "journal-article" @default.
- W1569416291 hasAuthorship W1569416291A5007509900 @default.
- W1569416291 hasAuthorship W1569416291A5023476792 @default.
- W1569416291 hasAuthorship W1569416291A5091136022 @default.
- W1569416291 hasBestOaLocation W15694162911 @default.
- W1569416291 hasConcept C118131993 @default.
- W1569416291 hasConcept C121608353 @default.
- W1569416291 hasConcept C134018914 @default.
- W1569416291 hasConcept C1491633281 @default.
- W1569416291 hasConcept C153911025 @default.
- W1569416291 hasConcept C190283241 @default.
- W1569416291 hasConcept C2776235491 @default.
- W1569416291 hasConcept C2776750431 @default.
- W1569416291 hasConcept C2778264664 @default.
- W1569416291 hasConcept C2779723316 @default.
- W1569416291 hasConcept C2781018059 @default.
- W1569416291 hasConcept C29537977 @default.
- W1569416291 hasConcept C502942594 @default.
- W1569416291 hasConcept C54009773 @default.
- W1569416291 hasConcept C54355233 @default.
- W1569416291 hasConcept C555283112 @default.
- W1569416291 hasConcept C62112901 @default.
- W1569416291 hasConcept C81885089 @default.
- W1569416291 hasConcept C86803240 @default.
- W1569416291 hasConceptScore W1569416291C118131993 @default.
- W1569416291 hasConceptScore W1569416291C121608353 @default.
- W1569416291 hasConceptScore W1569416291C134018914 @default.
- W1569416291 hasConceptScore W1569416291C1491633281 @default.
- W1569416291 hasConceptScore W1569416291C153911025 @default.
- W1569416291 hasConceptScore W1569416291C190283241 @default.
- W1569416291 hasConceptScore W1569416291C2776235491 @default.
- W1569416291 hasConceptScore W1569416291C2776750431 @default.
- W1569416291 hasConceptScore W1569416291C2778264664 @default.
- W1569416291 hasConceptScore W1569416291C2779723316 @default.
- W1569416291 hasConceptScore W1569416291C2781018059 @default.
- W1569416291 hasConceptScore W1569416291C29537977 @default.
- W1569416291 hasConceptScore W1569416291C502942594 @default.
- W1569416291 hasConceptScore W1569416291C54009773 @default.
- W1569416291 hasConceptScore W1569416291C54355233 @default.
- W1569416291 hasConceptScore W1569416291C555283112 @default.
- W1569416291 hasConceptScore W1569416291C62112901 @default.
- W1569416291 hasConceptScore W1569416291C81885089 @default.
- W1569416291 hasConceptScore W1569416291C86803240 @default.
- W1569416291 hasIssue "5" @default.
- W1569416291 hasLocation W15694162911 @default.
- W1569416291 hasOpenAccess W1569416291 @default.