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• W1569421452 abstract "Objective:To determine the rates and predictors of conversion from normal cognition (NC) to mild cognitive impairment (MCI) or dementia in Parkinson’s disease (PD) patients.Background:PD patients are at high long-term risk for developing PD-MCI or dementia (PDD), yet cognitive course and risk factors for cognitive decline in PD patients with NC have not been reported.Methods:Impression of cognitive decline, results of neuropsychological testing, and ratings of functional abilities were collected from 132 PD patients followed long-term (annually for 2-4 years). Patients with cognitive impairment (MCI or dementia) or total Mattis DRS-2 score <134 at baseline were excluded. An expert panel classified all patients annually as NC, MCI, or dementia following recommended criteria.Results:At baseline, mean age =69.0 (±6.7), education =16.5 (±2.3), and disease duration =5.4 (±4.2) years; the sample was 62.9% male. Cumulative progression to cognitive impairment occurred in 9.2% (year 1), 21.4% (year 2), 29.9% (year 3), and 35.1% (year 4) of patients. Conversion rates to dementia for new MCI cases were 15.6% (year 1), 35.7% (year 2) and 66.7% (year 3). In a logistic regression model, baseline predictors of conversion to cognitive impairment were increasing disease severity (OR=3.38, p=0.01), male sex (OR=2.57, p=0.04), and lower baseline total DRS-2 score (OR=0.77, p=0.002). Specific additional cognitive predictors of future decline were worse lexical fluency (OR=0.94, p=0.006), naming (OR=0.83, p=0.02) and memory (OR=0.86, p=0.03).Conclusion:More than one-third of PD patients with NC develop cognitive impairment within 4 years, and the majority of new MCI cases convert to dementia within 3 years. Worse executive, language and memory abilities all predict future decline. These results are consistent with previous studies reporting that the overwhelming majority of PD patients develop cognitive impairment long-term, and have implications for understanding disease course and clinical care. Disclosure: Dr. Pigott has nothing to disclose. Dr. Rick has nothing to disclose. Dr. Hurtig has nothing to disclose. Dr. Chen-Plotkin has received research support from Pfizer Inc. Dr. Duda has received personal compensation for activities with Teva Neuroscience. Dr. Duda holds stock and/or stock options in Celgene Corporation. Dr. Morley has nothing to disclose. Dr. Dahodwala has received research support from Teva Neuroscience. Dr. Akhtar has nothing to disclose. Dr. Siderowf has received personal compensation for activities with Avid Radiopharmaceuticals. Dr. Siderowf has received research support from the National Institute of Neurological Disorders and Stroke. Dr. Goldmann Gross has nothing to disclose. Dr. Xie has nothing to disclose. Dr. Trojanowksi has received personal compensation for activities with Pfizer Inc., Johnson & Johnson, MetLife, and Bristol-Myers Squibb Co. as a consultant. Dr. Trojanowski has received royalty payments through Penn licenses. Dr. Trojanowksi has received research support from AstraZeneca and Bristol-Myers Squibb Co. Dr. Weintraub has received personal compensation for activities with Teva Neuroscience, Lundbeck Research USA Inc., Biogen Idec, Avanir Pharmaceuticals, Pfizer Inc., UCB Pharma, and Eli Lilly & Company. Dr. Weintraub has received license fee payments from the University of Pennsylvania. Dr. Weintraub has received research support from Novartis." @default.
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• W1569421452 date "2014-04-08" @default.
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• W1569421452 title "Long-term Outcomes of Parkinson's Disease Patients with Normal Cognition. (P5.260)" @default.
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