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- W1569426124 abstract "In the period of March 1991 to December 1996, a total of 14,365 sera frompregnant women were investigated for estimating the risk of fetal Downsyndrome and neural tube defects. Assays of alphafetoprotein (AFP),unconjugated estriol (uE3) and intact human chorionic gonadotropin (hCG)were performed with the radioimmunoassay kits, AmerlexM. Risk of Downsyndrome and neural tube defects was calculated with the computer program, alpha. Retrospectively, the risk for trisomy 18 was also estimated onthe basis of the same biochemical parameters. During the survey period,a new law on population research came into effect in 1996, making itnecessary to license the offer of serum screening. As a consequence,those requesting risk estimations have shifted from obstetricians tomidwives. In addition , a shift in the geographical origin of thesamples from the Utrecht region to the western and southern parts of theNetherlands has occurred. As far as we currently know, 29 out of the 35known Down syndrome cases were detected. Besides the Down syndrome other(numerical) chromosomal anomalies were detected. Since the maternal ageof the pregnant women was very high and not representative of the normalDutch population, a very high detection rate of Down's syndrome cases wasfound (86.3%); however, the false positive rate was also high (11.3%). It is possible to correct for the age distribution, and to calculate anexpected false positive rate of 7.9% for the actual age distribution ofthe Dutch pregnant women, with a concommittant lower detection rate. Allcases of neural tube defects have been detected, with the exception ofone case of open spina bifida, which was probably caused by the use ofvalproate during pregnancy." @default.
- W1569426124 created "2016-06-24" @default.
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- W1569426124 date "1998-05-31" @default.
- W1569426124 modified "2023-09-24" @default.
- W1569426124 title "Risico-bepaling op foetaal Down syndroom enneuraalbuisdefecten door middel van alpha-1-foetoproteine, ongeconjugeerd oestriol en humaan choriongonadotropine inmaternaal serum. Rapportage over de periode maart 1991 t/m 1996" @default.
- W1569426124 hasPublicationYear "1998" @default.
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