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• W1569432641 abstract "Blood has been the object of a search for biomarkers for psychiatric disorders since long before the advent of proteomics. A series of investigations have been conducted on serum or plasma, either by focusing on protein candidates such as cytokines or brain-derived neurotrophic factor (BDNF) or by testing multiple candidates simultaneously. Notwithstanding the amount of suggestive evidence for depression, no real biomarker application has made an impact on clinical practice so far. Relatively consistent findings have been obtained for a few candidate proteins, such as BDNF - which, however, appears to be nonspecifically dysregulated across many neuropsychiatric conditions. Combination of biomarkers and the broader picture represented by proteomic profiles are providing a better chance to divide the disorder into subtypes and gain specificity versus other diseases. Most efforts have focused on the identification of proteomic signatures able to discriminate patients from controls, even leading to the proposal of diagnostic tests for mental disorders; however, no major attempts have been made to fulfill the clinical need for signatures able to predict response to antidepressants. In this review, the most interesting findings obtained by searching serum or plasma by proteomic approaches are put into the context of their potential clinical application, highlighting potential pitfalls and opportunities. New directions in proteomic biomarker efforts beyond cross-sectional studies in case-control collections as defined by diagnosis are advocated, and the need for an effective integration of biomarkers at different levels is emphasized. Capturing the contribution of genetic variability to protein expression, and ultimately integrating this information with imaging measures of brain structure and function, will open new avenues for the discovery of mechanisms and circuits involved in disease pathophysiology and drug response." @default.
• W1569432641 created "2016-06-24" @default.
• W1569432641 creator A5009295406 @default.
• W1569432641 date "2014-01-01" @default.
• W1569432641 modified "2023-09-25" @default.
• W1569432641 title "Peripheral Biomarkers for Depression by Plasma and Serum Proteomics" @default.
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• W1569432641 doi "https://doi.org/10.1159/000358178" @default.
• W1569432641 hasPublicationYear "2014" @default.
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