FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569433052> ?p ?o ?g. }

• W1569433052 endingPage "5423" @default.
• W1569433052 startingPage "5418" @default.
• W1569433052 abstract "We have reported previously that a dietary deficiency in selenium results in an increase in glutathione S-transferase (GST) activity of various rat tissues. In order to verify that the increased GST activity observed in a selenium deficiency results from increased synthesis of GST protein, cytosolic fractions of livers obtained from rats fed selenium-deficient and selenium-supplemented diets were analyzed by Western (protein) blots. Antisera raised against purified individual GST subunits (Ya, Yb, and Yc) were used to detect the corresponding subunits on the blots. The Ya subunit was induced 2.5-fold in the selenium-deficient state. The amount of Yc subunit also increased significantly (p less than 0.05) in selenium deficiency but not to the extent of the Ya subunit. The Yb subunit was not significantly affected by altered selenium nutritional status. A corresponding increase in poly(A) RNAs coding for the Ya and Yc subunits was also observed by Northern blot analysis. Transcriptional activity of GST YaYc genes was elevated by approximately 2-fold in purified nuclei isolated from selenium-deficient rat livers, which is sufficient to account for the increase in YaYc mRNA levels. Therefore, it appears that transcriptional activation of rat liver YaYc genes is the primary cause for the elevation of the corresponding gene products in the selenium-deficient state. Since the GSTs, especially the isozymes containing Ya subunit, have been implicated in the formation of prostaglandin (PG) F2 alpha, we investigated the effect of selenium deficiency on the PGF2 alpha-forming activity using a specific inhibitor of GSTs, S-decyl-GSH. In rats fed a nutritionally adequate diet, the activity inhibited by S-decyl-GSH accounted for at least half of the conversion of PGH2 to PGF2 alpha. During selenium deficiency, this GST-catalyzed activity was approximately doubled with no change in PGF2 alpha formation by other pathways, resulting in a 2-fold increase in overall synthesis of PGF2 alpha. These data strongly support a role of GSTs, especially those composed of the Ya size subunit, in the synthesis of PGF2 alpha from PGH2." @default.
• W1569433052 created "2016-06-24" @default.
• W1569433052 creator A5002026660 @default.
• W1569433052 creator A5011596831 @default.
• W1569433052 creator A5032647042 @default.
• W1569433052 creator A5064103282 @default.
• W1569433052 date "1990-04-01" @default.
• W1569433052 modified "2023-09-30" @default.
• W1569433052 title "The induction of specific rat liver glutathione S-transferase subunits under inadequate selenium nutrition causes an increase in prostaglandin F2 alpha formation." @default.
• W1569433052 cites W129370812 @default.
• W1569433052 cites W1508250182 @default.
• W1569433052 cites W1508958720 @default.
• W1569433052 cites W1535254030 @default.
• W1569433052 cites W1539664383 @default.
• W1569433052 cites W1542538950 @default.
• W1569433052 cites W1577851981 @default.
• W1569433052 cites W1594959795 @default.
• W1569433052 cites W1598530978 @default.
• W1569433052 cites W1605429854 @default.
• W1569433052 cites W1775749144 @default.
• W1569433052 cites W1849951061 @default.
• W1569433052 cites W1906401409 @default.
• W1569433052 cites W1973674407 @default.
• W1569433052 cites W1998741896 @default.
• W1569433052 cites W2003769808 @default.
• W1569433052 cites W2005063559 @default.
• W1569433052 cites W2011836510 @default.
• W1569433052 cites W2019410656 @default.
• W1569433052 cites W2031892849 @default.
• W1569433052 cites W2036903205 @default.
• W1569433052 cites W2070842008 @default.
• W1569433052 cites W2074466695 @default.
• W1569433052 cites W2081990898 @default.
• W1569433052 cites W2100837269 @default.
• W1569433052 cites W2101108802 @default.
• W1569433052 cites W2112739058 @default.
• W1569433052 cites W2113766384 @default.
• W1569433052 cites W2158695300 @default.
• W1569433052 cites W2169438310 @default.
• W1569433052 cites W2576734941 @default.
• W1569433052 cites W4294216491 @default.
• W1569433052 doi "https://doi.org/10.1016/s0021-9258(19)39376-7" @default.
• W1569433052 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1690709" @default.
• W1569433052 hasPublicationYear "1990" @default.
• W1569433052 type Work @default.
• W1569433052 sameAs 1569433052 @default.
• W1569433052 citedByCount "49" @default.
• W1569433052 countsByYear W15694330522012 @default.
• W1569433052 countsByYear W15694330522015 @default.
• W1569433052 crossrefType "journal-article" @default.
• W1569433052 hasAuthorship W1569433052A5002026660 @default.
• W1569433052 hasAuthorship W1569433052A5011596831 @default.
• W1569433052 hasAuthorship W1569433052A5032647042 @default.
• W1569433052 hasAuthorship W1569433052A5064103282 @default.
• W1569433052 hasBestOaLocation W15694330521 @default.
• W1569433052 hasConcept C126322002 @default.
• W1569433052 hasConcept C134018914 @default.
• W1569433052 hasConcept C159110408 @default.
• W1569433052 hasConcept C178790620 @default.
• W1569433052 hasConcept C181199279 @default.
• W1569433052 hasConcept C185592680 @default.
• W1569433052 hasConcept C199360897 @default.
• W1569433052 hasConcept C2775944032 @default.
• W1569433052 hasConcept C2776174256 @default.
• W1569433052 hasConcept C2776376580 @default.
• W1569433052 hasConcept C2780664492 @default.
• W1569433052 hasConcept C41008148 @default.
• W1569433052 hasConcept C49453240 @default.
• W1569433052 hasConcept C538909803 @default.
• W1569433052 hasConcept C553756173 @default.
• W1569433052 hasConcept C55493867 @default.
• W1569433052 hasConcept C64943373 @default.
• W1569433052 hasConcept C71924100 @default.
• W1569433052 hasConcept C86803240 @default.
• W1569433052 hasConceptScore W1569433052C126322002 @default.
• W1569433052 hasConceptScore W1569433052C134018914 @default.
• W1569433052 hasConceptScore W1569433052C159110408 @default.
• W1569433052 hasConceptScore W1569433052C178790620 @default.
• W1569433052 hasConceptScore W1569433052C181199279 @default.
• W1569433052 hasConceptScore W1569433052C185592680 @default.
• W1569433052 hasConceptScore W1569433052C199360897 @default.
• W1569433052 hasConceptScore W1569433052C2775944032 @default.
• W1569433052 hasConceptScore W1569433052C2776174256 @default.
• W1569433052 hasConceptScore W1569433052C2776376580 @default.
• W1569433052 hasConceptScore W1569433052C2780664492 @default.
• W1569433052 hasConceptScore W1569433052C41008148 @default.
• W1569433052 hasConceptScore W1569433052C49453240 @default.
• W1569433052 hasConceptScore W1569433052C538909803 @default.
• W1569433052 hasConceptScore W1569433052C553756173 @default.
• W1569433052 hasConceptScore W1569433052C55493867 @default.
• W1569433052 hasConceptScore W1569433052C64943373 @default.
• W1569433052 hasConceptScore W1569433052C71924100 @default.
• W1569433052 hasConceptScore W1569433052C86803240 @default.
• W1569433052 hasIssue "10" @default.
• W1569433052 hasLocation W15694330521 @default.
• W1569433052 hasOpenAccess W1569433052 @default.
• W1569433052 hasPrimaryLocation W15694330521 @default.
• W1569433052 hasRelatedWork W1835699834 @default.

• next