FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569435085> ?p ?o ?g. }

• W1569435085 endingPage "1216" @default.
• W1569435085 startingPage "1207" @default.
• W1569435085 abstract "Biomedical strategies for tissue engineering and repair utilize specific cells, scaffolds, and growth factors to reconstruct elements of damaged tissue. The cellular element of these strategies is limited, however, by poor efficiency of delivery and retention of therapeutic cells in target sites. We propose that the presence of a cellular anchor that is able to specifically bind a defined element of target tissue will facilitate efficient binding and retention of therapeutic cells, thereby promoting repair of the target site. To do so, we engineered an artificial collagen-specific anchor (ACSA) that is able to specifically bind collagen I. The ACSA was engineered by creating a construct comprising rationally designed consecutive domains. The binding specificity of the ACSA was achieved by employing variable regions of a monoclonal antibody that recognizes a unique epitope present in human collagen I. Meanwhile, cell membrane localization of the ACSA was provided by the presence of a transmembrane domain. We determined that the ACSA was localized within cell membranes and interacted with its intended target, that is, collagen I. We have demonstrated that, in comparison to the control, the cells expressing the ACSA attached better to collagen I and exhibited improved retention in sites of seeding. We have also demonstrated that the presence of the ACSA did not interfere with cell proliferation, the biosynthesis of endogenous collagen I, or the biological functions of native collagen receptors. Since the presented cell delivery system utilizes a common characteristic of major connective tissues, namely the presence of collagen I, the findings described here could have a broad positive impact for improving the repair processes of tendon, ligament, bone, intervertebral disc, skin, and other collagen I-rich connective tissues. If successful, the ACSA approach to deliver cells will serve as an outline for developing cell delivery methods that target other elements of extracellular matrices, including other collagen types, laminins, and fibronectins." @default.
• W1569435085 created "2016-06-24" @default.
• W1569435085 creator A5029800728 @default.
• W1569435085 creator A5062837992 @default.
• W1569435085 creator A5072750067 @default.
• W1569435085 creator A5080335637 @default.
• W1569435085 creator A5090529638 @default.
• W1569435085 date "2015-04-01" @default.
• W1569435085 modified "2023-10-17" @default.
• W1569435085 title "Matrix-Specific Anchors: A New Concept for Targeted Delivery and Retention of Therapeutic Cells" @default.
• W1569435085 cites W1540298123 @default.
• W1569435085 cites W1641205561 @default.
• W1569435085 cites W177057739 @default.
• W1569435085 cites W1965434058 @default.
• W1569435085 cites W1969806729 @default.
• W1569435085 cites W1974507263 @default.
• W1569435085 cites W1980666905 @default.
• W1569435085 cites W2000980526 @default.
• W1569435085 cites W2003081048 @default.
• W1569435085 cites W2005275397 @default.
• W1569435085 cites W2008182044 @default.
• W1569435085 cites W2010871418 @default.
• W1569435085 cites W2014512961 @default.
• W1569435085 cites W2015029875 @default.
• W1569435085 cites W2023734558 @default.
• W1569435085 cites W2025154480 @default.
• W1569435085 cites W2038426832 @default.
• W1569435085 cites W2038486474 @default.
• W1569435085 cites W2049727455 @default.
• W1569435085 cites W2050847411 @default.
• W1569435085 cites W2052800047 @default.
• W1569435085 cites W2054330411 @default.
• W1569435085 cites W2057389857 @default.
• W1569435085 cites W2057631549 @default.
• W1569435085 cites W2061214013 @default.
• W1569435085 cites W2062173205 @default.
• W1569435085 cites W2069254393 @default.
• W1569435085 cites W2076961720 @default.
• W1569435085 cites W2089738396 @default.
• W1569435085 cites W2093654081 @default.
• W1569435085 cites W2103719520 @default.
• W1569435085 cites W2106776282 @default.
• W1569435085 cites W2107065228 @default.
• W1569435085 cites W2109002581 @default.
• W1569435085 cites W2131797874 @default.
• W1569435085 cites W2139452522 @default.
• W1569435085 cites W2146059841 @default.
• W1569435085 cites W2150103989 @default.
• W1569435085 cites W2158776028 @default.
• W1569435085 cites W2160147088 @default.
• W1569435085 cites W2160284674 @default.
• W1569435085 cites W2161873278 @default.
• W1569435085 cites W2167301573 @default.
• W1569435085 cites W2409360762 @default.
• W1569435085 doi "https://doi.org/10.1089/ten.tea.2014.0401" @default.
• W1569435085 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4394883" @default.
• W1569435085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25435302" @default.
• W1569435085 hasPublicationYear "2015" @default.
• W1569435085 type Work @default.
• W1569435085 sameAs 1569435085 @default.
• W1569435085 citedByCount "5" @default.
• W1569435085 countsByYear W15694350852015 @default.
• W1569435085 countsByYear W15694350852016 @default.
• W1569435085 countsByYear W15694350852018 @default.
• W1569435085 countsByYear W15694350852023 @default.
• W1569435085 crossrefType "journal-article" @default.
• W1569435085 hasAuthorship W1569435085A5029800728 @default.
• W1569435085 hasAuthorship W1569435085A5062837992 @default.
• W1569435085 hasAuthorship W1569435085A5072750067 @default.
• W1569435085 hasAuthorship W1569435085A5080335637 @default.
• W1569435085 hasAuthorship W1569435085A5090529638 @default.
• W1569435085 hasBestOaLocation W15694350852 @default.
• W1569435085 hasConcept C106487976 @default.
• W1569435085 hasConcept C136229726 @default.
• W1569435085 hasConcept C1491633281 @default.
• W1569435085 hasConcept C159654299 @default.
• W1569435085 hasConcept C170493617 @default.
• W1569435085 hasConcept C185592680 @default.
• W1569435085 hasConcept C189165786 @default.
• W1569435085 hasConcept C195616568 @default.
• W1569435085 hasConcept C198826908 @default.
• W1569435085 hasConcept C203014093 @default.
• W1569435085 hasConcept C24530287 @default.
• W1569435085 hasConcept C43617362 @default.
• W1569435085 hasConcept C49892992 @default.
• W1569435085 hasConcept C54355233 @default.
• W1569435085 hasConcept C55493867 @default.
• W1569435085 hasConcept C71924100 @default.
• W1569435085 hasConcept C81885089 @default.
• W1569435085 hasConcept C86803240 @default.
• W1569435085 hasConcept C95444343 @default.
• W1569435085 hasConceptScore W1569435085C106487976 @default.
• W1569435085 hasConceptScore W1569435085C136229726 @default.
• W1569435085 hasConceptScore W1569435085C1491633281 @default.
• W1569435085 hasConceptScore W1569435085C159654299 @default.
• W1569435085 hasConceptScore W1569435085C170493617 @default.
• W1569435085 hasConceptScore W1569435085C185592680 @default.
• W1569435085 hasConceptScore W1569435085C189165786 @default.

• next