Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569436451> ?p ?o ?g. }
- W1569436451 endingPage "602" @default.
- W1569436451 startingPage "598" @default.
- W1569436451 abstract "Background Topotecan has been variably incorporated in the treatment of patients with relapsed Wilms tumour (WT) who failed initial treatment with three or more effective drugs. Our objective was to describe outcome and to retrospectively investigate the potential role of topotecan in relapsed WT patients. Methods Children who were treated with topotecan as part of their chemotherapeutic regimens for relapsed WT were identified and included in our retrospective study. Patient charts were reviewed for general patient characteristics, histology and stage at initial diagnosis, number and type of relapse, salvage treatment schedules, toxicity, response to treatment and outcome. Results From 2000 to 2012, 30 children (median age at relapse 5.5 years, range 1.6–14.5 years) were identified to have received topotecan as part of their salvage regimens (primary progressive disease n = 3, first, second and third relapse n = 13, 9 and 2 respectively, partial response n = 3). Topotecan was administered as a single agent (12 patients) or in combination with other drugs (18 patients). Sixteen patients had high-risk histology according to the SIOP classification, 15 died within 12 months because of progressive disease. Fourteen patients had SIOP intermediate-risk histology of which four patients displayed objective responses to topotecan. Overall, 6 out of 14 intermediate-risk patients survived (median follow up of 6 years), however, three of whom (stage V) had bilateral nephrectomy after topotecan treatment. Conclusions Topotecan does not seem to show effectiveness in the treatment of relapsed WT patients with initial high-risk histology. In patients with intermediate-risk histology, the role of topotecan might deserve further attention, to prove its efficacy. Pediatr Blood Cancer 2015;62:598–602. © 2014 Wiley Periodicals, Inc." @default.
- W1569436451 created "2016-06-24" @default.
- W1569436451 creator A5016794541 @default.
- W1569436451 creator A5021237633 @default.
- W1569436451 creator A5027350994 @default.
- W1569436451 creator A5028858578 @default.
- W1569436451 creator A5029830172 @default.
- W1569436451 creator A5031176507 @default.
- W1569436451 creator A5035410237 @default.
- W1569436451 creator A5035945818 @default.
- W1569436451 creator A5041539522 @default.
- W1569436451 creator A5057873409 @default.
- W1569436451 creator A5061565715 @default.
- W1569436451 creator A5069561562 @default.
- W1569436451 date "2014-12-29" @default.
- W1569436451 modified "2023-09-30" @default.
- W1569436451 title "Treatment of relapsed Wilms tumour (WT) patients: Experience with topotecan. A report from the SIOP Renal Tumour Study Group (RTSG)" @default.
- W1569436451 cites W1888038496 @default.
- W1569436451 cites W1901103115 @default.
- W1569436451 cites W1942082802 @default.
- W1569436451 cites W1962453771 @default.
- W1569436451 cites W1965540525 @default.
- W1569436451 cites W1968522647 @default.
- W1569436451 cites W1979545966 @default.
- W1569436451 cites W1987828792 @default.
- W1569436451 cites W1988124545 @default.
- W1569436451 cites W2004875493 @default.
- W1569436451 cites W2020122374 @default.
- W1569436451 cites W2033485414 @default.
- W1569436451 cites W2036109412 @default.
- W1569436451 cites W2038374636 @default.
- W1569436451 cites W2038919352 @default.
- W1569436451 cites W2050049307 @default.
- W1569436451 cites W2058457132 @default.
- W1569436451 cites W2061687087 @default.
- W1569436451 cites W2088257209 @default.
- W1569436451 cites W2099721791 @default.
- W1569436451 cites W2129827252 @default.
- W1569436451 cites W2134892480 @default.
- W1569436451 cites W2152756304 @default.
- W1569436451 cites W2157030129 @default.
- W1569436451 cites W2158653287 @default.
- W1569436451 cites W2160629218 @default.
- W1569436451 cites W2162339522 @default.
- W1569436451 cites W2257426985 @default.
- W1569436451 cites W2597812924 @default.
- W1569436451 doi "https://doi.org/10.1002/pbc.25357" @default.
- W1569436451 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25546733" @default.
- W1569436451 hasPublicationYear "2014" @default.
- W1569436451 type Work @default.
- W1569436451 sameAs 1569436451 @default.
- W1569436451 citedByCount "12" @default.
- W1569436451 countsByYear W15694364512017 @default.
- W1569436451 countsByYear W15694364512018 @default.
- W1569436451 countsByYear W15694364512019 @default.
- W1569436451 countsByYear W15694364512020 @default.
- W1569436451 countsByYear W15694364512021 @default.
- W1569436451 countsByYear W15694364512022 @default.
- W1569436451 crossrefType "journal-article" @default.
- W1569436451 hasAuthorship W1569436451A5016794541 @default.
- W1569436451 hasAuthorship W1569436451A5021237633 @default.
- W1569436451 hasAuthorship W1569436451A5027350994 @default.
- W1569436451 hasAuthorship W1569436451A5028858578 @default.
- W1569436451 hasAuthorship W1569436451A5029830172 @default.
- W1569436451 hasAuthorship W1569436451A5031176507 @default.
- W1569436451 hasAuthorship W1569436451A5035410237 @default.
- W1569436451 hasAuthorship W1569436451A5035945818 @default.
- W1569436451 hasAuthorship W1569436451A5041539522 @default.
- W1569436451 hasAuthorship W1569436451A5057873409 @default.
- W1569436451 hasAuthorship W1569436451A5061565715 @default.
- W1569436451 hasAuthorship W1569436451A5069561562 @default.
- W1569436451 hasBestOaLocation W15694364511 @default.
- W1569436451 hasConcept C126322002 @default.
- W1569436451 hasConcept C141071460 @default.
- W1569436451 hasConcept C146357865 @default.
- W1569436451 hasConcept C151730666 @default.
- W1569436451 hasConcept C167135981 @default.
- W1569436451 hasConcept C2776694085 @default.
- W1569436451 hasConcept C2778822529 @default.
- W1569436451 hasConcept C2781209748 @default.
- W1569436451 hasConcept C57742111 @default.
- W1569436451 hasConcept C71924100 @default.
- W1569436451 hasConcept C86803240 @default.
- W1569436451 hasConceptScore W1569436451C126322002 @default.
- W1569436451 hasConceptScore W1569436451C141071460 @default.
- W1569436451 hasConceptScore W1569436451C146357865 @default.
- W1569436451 hasConceptScore W1569436451C151730666 @default.
- W1569436451 hasConceptScore W1569436451C167135981 @default.
- W1569436451 hasConceptScore W1569436451C2776694085 @default.
- W1569436451 hasConceptScore W1569436451C2778822529 @default.
- W1569436451 hasConceptScore W1569436451C2781209748 @default.
- W1569436451 hasConceptScore W1569436451C57742111 @default.
- W1569436451 hasConceptScore W1569436451C71924100 @default.
- W1569436451 hasConceptScore W1569436451C86803240 @default.
- W1569436451 hasIssue "4" @default.
- W1569436451 hasLocation W15694364511 @default.
- W1569436451 hasLocation W15694364512 @default.
- W1569436451 hasOpenAccess W1569436451 @default.