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• W1569443016 abstract "OBJECTIVE: Our aim was to investigate the expression of cytotoxic T lymphocyte‐associated molecule 4 (CTLA‐4) in ulcerative colitis (UC) and to evaluate the effect of CTLA‐4 gene ‐1661A/G polymorphism on CTLA‐4 expression and transcription. METHODS: A total of 20 UC patients and 22 healthy controls matched by age and sex were enrolled at Zhongnan Hospital of Wuhan University in central China. The CTLA‐4 ‐1661A/G polymorphism was genotyped by the polymerase chain reaction‐restriction fragment length polymorphism method. A Western blot analysis was performed to determine the full length CTLA‐4 (flCTLA‐4) protein expression in the peripheral blood of the UC patients. Serum‐soluble CTLA‐4 (sCTLA‐4) levels were measured by enzyme‐linked immunosorbent assay. CTLA‐4‐1661G mutant promoter transcription function was analyzed by site‐directed PCR‐based mutagenesis. RESULTS: CTLA‐4 protein expression on CD4 + T cells in UC patients was lower than that in the healthy controls ( P < 0.001) while serum sCTLA‐4 in the UC patients was significantly higher than that in the healthy controls ( P < 0.001). No correlation was found between flCTLA‐4 and sCTLA‐4 expression levels and the ‐1661 A/G polymorphism of the CTLA‐4 gene. Meanwhile, CTLA‐4 ‐1661 allele A had no significant impact on the promoter activity compared with allele G ( P > 0.05). CONCLUSION: CTLA‐4 expressions were aberrant in UC patients compared with the healthy controls. CTLA‐4 ‐1661A/G polymorphism had no significant impact on CTLA‐4 expression and transcription in the peripheral CD4 T cells of UC patients." @default.
• W1569443016 created "2016-06-24" @default.
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• W1569443016 date "2010-11-22" @default.
• W1569443016 modified "2023-10-17" @default.
• W1569443016 title "Effect of cytotoxic T lymphocyte-associated molecule 4 1661 gene polymorphism on its expression and transcription in ulcerative colitis" @default.
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• W1569443016 doi "https://doi.org/10.1111/j.1751-2980.2010.00462.x" @default.
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