Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569450060> ?p ?o ?g. }
- W1569450060 endingPage "269" @default.
- W1569450060 startingPage "255" @default.
- W1569450060 abstract "Over the past 30 years joint replacement prostheses have been developed and refined to enhance durability and reproducibility. Total hip joint arthroplasty is being performed in an increasing number of younger patients; therefore orthopaedic surgeons seek implants with a longer life span. With regards to the progress of mechanical behaviour of the biomaterials used in an arthroplasty, little is known about the long-term biological effects of wear debris. Owing to the composition of the prostheses currently in use, systemic exposure to chromium (Cr), cobalt (Co), nickel (Ni) and aluminium (Al) alloys occurs as a result of the formation of metal wear nano-particles that are released both from metal-on-metal and polyethylene-on-metal bearings, resulting in a postoperative increase in metal ion levels at different organ sites. These particles circulate both locally and systemically, penetrate cell plasma membranes, bind to cellular proteins and enzymes and modulate cytokine expression. Their physiologic effects are poorly understood and their potential toxicity, hypersensitivity and carcinogenicity remain a cause for concern. In this article we will address the issue of whether these nanoscale degradation products are associated with adverse, clinically significant local or systemic toxicologic sequelae." @default.
- W1569450060 created "2016-06-24" @default.
- W1569450060 creator A5006412575 @default.
- W1569450060 creator A5011656633 @default.
- W1569450060 creator A5020505190 @default.
- W1569450060 creator A5047059084 @default.
- W1569450060 creator A5051418384 @default.
- W1569450060 date "2012-02-10" @default.
- W1569450060 modified "2023-10-10" @default.
- W1569450060 title "Local and systemic toxicity of nanoscale debris particles in total hip arthroplasty" @default.
- W1569450060 cites W138934520 @default.
- W1569450060 cites W161001332 @default.
- W1569450060 cites W1837301576 @default.
- W1569450060 cites W1885823686 @default.
- W1569450060 cites W1963690246 @default.
- W1569450060 cites W1965251258 @default.
- W1569450060 cites W1965897070 @default.
- W1569450060 cites W1968316069 @default.
- W1569450060 cites W1969911040 @default.
- W1569450060 cites W1970837615 @default.
- W1569450060 cites W1973501934 @default.
- W1569450060 cites W1976952320 @default.
- W1569450060 cites W1977258749 @default.
- W1569450060 cites W1978877212 @default.
- W1569450060 cites W1980670770 @default.
- W1569450060 cites W1980782035 @default.
- W1569450060 cites W1983505677 @default.
- W1569450060 cites W1985255283 @default.
- W1569450060 cites W1988336043 @default.
- W1569450060 cites W1988746609 @default.
- W1569450060 cites W1993873451 @default.
- W1569450060 cites W1994737030 @default.
- W1569450060 cites W1994937897 @default.
- W1569450060 cites W1996139192 @default.
- W1569450060 cites W1996893606 @default.
- W1569450060 cites W1997538271 @default.
- W1569450060 cites W2003675139 @default.
- W1569450060 cites W2007122991 @default.
- W1569450060 cites W2007835216 @default.
- W1569450060 cites W2009392080 @default.
- W1569450060 cites W2010394776 @default.
- W1569450060 cites W2011200430 @default.
- W1569450060 cites W2012346785 @default.
- W1569450060 cites W2013243614 @default.
- W1569450060 cites W2014106248 @default.
- W1569450060 cites W2015436292 @default.
- W1569450060 cites W2018565672 @default.
- W1569450060 cites W2022323820 @default.
- W1569450060 cites W2025834329 @default.
- W1569450060 cites W2026017994 @default.
- W1569450060 cites W2026375528 @default.
- W1569450060 cites W2026890404 @default.
- W1569450060 cites W2028506278 @default.
- W1569450060 cites W2028656546 @default.
- W1569450060 cites W2029200238 @default.
- W1569450060 cites W2030263375 @default.
- W1569450060 cites W2032778209 @default.
- W1569450060 cites W2035272671 @default.
- W1569450060 cites W2040658267 @default.
- W1569450060 cites W2041815986 @default.
- W1569450060 cites W2042414022 @default.
- W1569450060 cites W2051059335 @default.
- W1569450060 cites W2057662521 @default.
- W1569450060 cites W2059876612 @default.
- W1569450060 cites W2066944233 @default.
- W1569450060 cites W2067060935 @default.
- W1569450060 cites W2073447811 @default.
- W1569450060 cites W2074952191 @default.
- W1569450060 cites W2078136787 @default.
- W1569450060 cites W2081087244 @default.
- W1569450060 cites W2081208716 @default.
- W1569450060 cites W2084504525 @default.
- W1569450060 cites W2090621644 @default.
- W1569450060 cites W2093342212 @default.
- W1569450060 cites W2097675734 @default.
- W1569450060 cites W2100043100 @default.
- W1569450060 cites W2100892595 @default.
- W1569450060 cites W2101683885 @default.
- W1569450060 cites W2103907018 @default.
- W1569450060 cites W2105188510 @default.
- W1569450060 cites W2105843439 @default.
- W1569450060 cites W2108463746 @default.
- W1569450060 cites W2108693844 @default.
- W1569450060 cites W2109101906 @default.
- W1569450060 cites W2109885399 @default.
- W1569450060 cites W2110498109 @default.
- W1569450060 cites W2114382070 @default.
- W1569450060 cites W2117630026 @default.
- W1569450060 cites W2119276700 @default.
- W1569450060 cites W2119972449 @default.
- W1569450060 cites W2122137630 @default.
- W1569450060 cites W2129160244 @default.
- W1569450060 cites W2130852550 @default.
- W1569450060 cites W2132045171 @default.
- W1569450060 cites W2136465127 @default.
- W1569450060 cites W2137849505 @default.
- W1569450060 cites W2141515556 @default.
- W1569450060 cites W2141655842 @default.