FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569456617> ?p ?o ?g. }

• W1569456617 endingPage "9609" @default.
• W1569456617 startingPage "9603" @default.
• W1569456617 abstract "Vascular smooth muscle cells (SMCs) produce the bulk of the connective tissue of major arteries, including collagen types I, III, and V. Recently, we have shown, they also have the capacity to synthesize the alpha 1 chain of type XI, a collagen related to type V (Brown, K., Lawrence, R., and Sonenshein, G. (1991) J. Biol. Chem. 266, 23268-23273). Furthermore, expression of types V and XI collagen were coordinately regulated with respect to serum deprivation and cell density in a fashion distinct from that for types I and III. To begin to determine the factors that influence vascular SMC production of types V/XI collagen, we have examined the effects of transforming growth factor (TGF)-beta 1, a major modulator of connective tissue expression. In serum-deprived confluent cultures of bovine pulmonary artery SMCs, TGF-beta 1 treatment increased the steady-state levels of the mRNAs of collagen types V and XI, as well as of types I and III, elastin and fibronectin. The largest increase was seen for alpha 2(V) procollagen. The increase in alpha 2(V) mRNA was detectable by 12 h after addition of 2 ng/ml TGF-beta 1, and concentrations as little as 0.5 ng/ml were effective. A similar increase in alpha 2(V) mRNA levels was observed with SMCs derived from the aortic arch and carotid artery. Type V collagen protein was found to be elevated by TGF-beta 1 treatment in both the conditioned media and the cell layer associated fraction of pulse-labeled cultures. A slight decrease in SMC proliferation as judged by DNA content, [3H]thymidine incorporation, and steady-state levels of histone H3.2 mRNA resulted from TGF-beta 1 treatment. These results suggest that the elevated levels of TGF-beta 1 in the vessel wall during atherosclerosis may be, in part, responsible for the increase in type V collagen that typifies advanced fibrotic lesions." @default.
• W1569456617 created "2016-06-24" @default.
• W1569456617 creator A5055157032 @default.
• W1569456617 creator A5056783314 @default.
• W1569456617 creator A5079640868 @default.
• W1569456617 date "1994-04-01" @default.
• W1569456617 modified "2023-10-16" @default.
• W1569456617 title "Transforming growth factor beta 1 stimulates type V collagen expression in bovine vascular smooth muscle cells" @default.
• W1569456617 cites W1502517254 @default.
• W1569456617 cites W1505978562 @default.
• W1569456617 cites W1508850474 @default.
• W1569456617 cites W1513452394 @default.
• W1569456617 cites W1517531742 @default.
• W1569456617 cites W1518270161 @default.
• W1569456617 cites W1521587369 @default.
• W1569456617 cites W1522946066 @default.
• W1569456617 cites W1554539977 @default.
• W1569456617 cites W1560768456 @default.
• W1569456617 cites W1577282104 @default.
• W1569456617 cites W1595561754 @default.
• W1569456617 cites W1601394191 @default.
• W1569456617 cites W1605243597 @default.
• W1569456617 cites W1608882278 @default.
• W1569456617 cites W1677581752 @default.
• W1569456617 cites W1761013599 @default.
• W1569456617 cites W1917942675 @default.
• W1569456617 cites W1973630430 @default.
• W1569456617 cites W1974790290 @default.
• W1569456617 cites W1981239835 @default.
• W1569456617 cites W1985498630 @default.
• W1569456617 cites W1994928837 @default.
• W1569456617 cites W2001008299 @default.
• W1569456617 cites W2002736874 @default.
• W1569456617 cites W2008135813 @default.
• W1569456617 cites W2009397336 @default.
• W1569456617 cites W2009808606 @default.
• W1569456617 cites W2010710364 @default.
• W1569456617 cites W2013538302 @default.
• W1569456617 cites W2021218223 @default.
• W1569456617 cites W2030359488 @default.
• W1569456617 cites W2034911624 @default.
• W1569456617 cites W2042849902 @default.
• W1569456617 cites W2056943009 @default.
• W1569456617 cites W2060333964 @default.
• W1569456617 cites W2061926510 @default.
• W1569456617 cites W2063448906 @default.
• W1569456617 cites W2072558376 @default.
• W1569456617 cites W2076300996 @default.
• W1569456617 cites W2090935242 @default.
• W1569456617 cites W2093586592 @default.
• W1569456617 cites W2094695497 @default.
• W1569456617 cites W2104887669 @default.
• W1569456617 cites W2106051489 @default.
• W1569456617 cites W2106480106 @default.
• W1569456617 cites W2119518116 @default.
• W1569456617 cites W2124331987 @default.
• W1569456617 cites W2136819827 @default.
• W1569456617 cites W2154907407 @default.
• W1569456617 cites W2162991824 @default.
• W1569456617 cites W2168476587 @default.
• W1569456617 cites W2169048611 @default.
• W1569456617 cites W2616622214 @default.
• W1569456617 doi "https://doi.org/10.1016/s0021-9258(17)36924-7" @default.
• W1569456617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8144547" @default.
• W1569456617 hasPublicationYear "1994" @default.
• W1569456617 type Work @default.
• W1569456617 sameAs 1569456617 @default.
• W1569456617 citedByCount "77" @default.
• W1569456617 countsByYear W15694566172015 @default.
• W1569456617 countsByYear W15694566172016 @default.
• W1569456617 countsByYear W15694566172019 @default.
• W1569456617 countsByYear W15694566172021 @default.
• W1569456617 crossrefType "journal-article" @default.
• W1569456617 hasAuthorship W1569456617A5055157032 @default.
• W1569456617 hasAuthorship W1569456617A5056783314 @default.
• W1569456617 hasAuthorship W1569456617A5079640868 @default.
• W1569456617 hasBestOaLocation W15694566171 @default.
• W1569456617 hasConcept C118131993 @default.
• W1569456617 hasConcept C134018914 @default.
• W1569456617 hasConcept C153911025 @default.
• W1569456617 hasConcept C185592680 @default.
• W1569456617 hasConcept C2778229498 @default.
• W1569456617 hasConcept C2779395532 @default.
• W1569456617 hasConcept C2992686903 @default.
• W1569456617 hasConcept C86803240 @default.
• W1569456617 hasConcept C95444343 @default.
• W1569456617 hasConceptScore W1569456617C118131993 @default.
• W1569456617 hasConceptScore W1569456617C134018914 @default.
• W1569456617 hasConceptScore W1569456617C153911025 @default.
• W1569456617 hasConceptScore W1569456617C185592680 @default.
• W1569456617 hasConceptScore W1569456617C2778229498 @default.
• W1569456617 hasConceptScore W1569456617C2779395532 @default.
• W1569456617 hasConceptScore W1569456617C2992686903 @default.
• W1569456617 hasConceptScore W1569456617C86803240 @default.
• W1569456617 hasConceptScore W1569456617C95444343 @default.
• W1569456617 hasIssue "13" @default.
• W1569456617 hasLocation W15694566171 @default.
• W1569456617 hasOpenAccess W1569456617 @default.

• next