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- W1569474565 abstract "Publisher Summary This chapter describes a molecular and genetic dissection of the membrane skeleton in polarized cells in Drosophila . An important principle to emerge from the erythrocyte model is that the lipid bilayer is fortified by a submembrane network of peripheral membrane proteins. These proteins, commonly referred to as the “membrane skeleton,” are essential for the normal shape and stability of the erythrocyte membrane. The membrane-skeleton proteins first described in the erythrocyte also have homologs associated with the plasma membrane (PM) of other cell types. Biochemical studies have revealed that these homologs participate in the same molecular interactions as their erythrocyte counterparts. However, technical limitations have prevented a direct electron microscopic (EM) analysis of the membrane skeleton in nonerythroid cells. Genetic studies of the nonerythroid membrane skeleton have also been lacking. Consequently, much of the conceptual framework for membrane-skeleton function is borrowed from the erythrocyte model." @default.
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- W1569474565 date "1996-01-01" @default.
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- W1569474565 title "Chapter 8 Molecular and Genetic Dissection of the Membrane Skeleton in Drosophila" @default.
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- W1569474565 doi "https://doi.org/10.1016/s0070-2161(08)60388-3" @default.
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