FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569478460> ?p ?o ?g. }

• W1569478460 endingPage "44" @default.
• W1569478460 startingPage "35" @default.
• W1569478460 abstract "Oxidative stress has been implicated in the pathogenesis of stroke, traumatic brain injuries, and neurodegenerative diseases affecting both neuronal and glial cells in the CNS. In this study we have demonstrated that reactive oxygen species (ROS) dramatically induce the expression of two neuropeptide genes, the opioid proenkephalin (pENK) and the opioid-related proorphanin FQ (pOFQ; also known as pronociceptin) in primary astrocytes. Hydrogen peroxide (H2O2) treatment dose-dependently increased pENK and pOFQ mRNA levels with a maximal effect (∼15-fold increase) being detected at 50 µm concentration. Exposing the astrocyte cultures to hypoxia and subsequent re-oxygenation also led to a profound elevation of pOFQ and pENK mRNA levels. Western blot analysis and immunocytochemistry revealed that H2O2 treatment elicited the phosphorylation and nuclear translocation of ERK 1/2 and p38 MAP kinases. Blockade of the p38 or the ERK MAP kinase pathways (by SB202190 and PD98059, respectively) prevented the H2O2-induced increase in pENK and pOFQ mRNA levels indicating a central role for these cascades in the regulation of pOFQ and pENK genes in response to oxidative stress. Regulation of pOFQ and pENK gene expression by ERK and p38 activation may be mediated through the transcription factor cAMP-response element binding protein (CREB). We observed CREB phosphorylation in response to H2O2, which was also prevented by SB202190 and PD98059. The nuclear factor-κB (NF-κB) pathway appears to be involved exclusively in the induction of pOFQ transcription by H2O2, as NF-κB inhibitors antagonized the effect of oxidative stress on pOFQ, but not on pENK expression. The profound induction of these genes by oxidative stress and these other factors may suggest a role for orphanin FQ and enkephalin in injury and stress responses of the CNS and neuropathophysiological conditions involving reactive oxygen species." @default.
• W1569478460 created "2016-06-24" @default.
• W1569478460 creator A5009193297 @default.
• W1569478460 creator A5027608139 @default.
• W1569478460 creator A5079043204 @default.
• W1569478460 date "2008-07-07" @default.
• W1569478460 modified "2023-09-25" @default.
• W1569478460 title "Oxidative stress induces proorphanin FQ and proenkephalin gene expression in astrocytes through p38- and ERK-MAP kinases and NF-κB" @default.
• W1569478460 cites W1517525911 @default.
• W1569478460 cites W1546975150 @default.
• W1569478460 cites W1549679997 @default.
• W1569478460 cites W1560653098 @default.
• W1569478460 cites W1815348286 @default.
• W1569478460 cites W1970793129 @default.
• W1569478460 cites W1983012742 @default.
• W1569478460 cites W1984243966 @default.
• W1569478460 cites W1990368389 @default.
• W1569478460 cites W1990834734 @default.
• W1569478460 cites W2001946904 @default.
• W1569478460 cites W2007032188 @default.
• W1569478460 cites W2016562510 @default.
• W1569478460 cites W2019582548 @default.
• W1569478460 cites W2022914311 @default.
• W1569478460 cites W2024606235 @default.
• W1569478460 cites W2028158224 @default.
• W1569478460 cites W2032922774 @default.
• W1569478460 cites W2036285327 @default.
• W1569478460 cites W2036985660 @default.
• W1569478460 cites W2039642494 @default.
• W1569478460 cites W2042525430 @default.
• W1569478460 cites W2042744887 @default.
• W1569478460 cites W2047889698 @default.
• W1569478460 cites W2058601469 @default.
• W1569478460 cites W2062754118 @default.
• W1569478460 cites W2066624199 @default.
• W1569478460 cites W2070046033 @default.
• W1569478460 cites W2071833703 @default.
• W1569478460 cites W2085612389 @default.
• W1569478460 cites W2086525709 @default.
• W1569478460 cites W2096633139 @default.
• W1569478460 cites W2101537600 @default.
• W1569478460 cites W2117498704 @default.
• W1569478460 cites W2120165202 @default.
• W1569478460 cites W2124583600 @default.
• W1569478460 cites W2131162745 @default.
• W1569478460 cites W2140660632 @default.
• W1569478460 cites W2144232114 @default.
• W1569478460 cites W2147049445 @default.
• W1569478460 cites W2149395040 @default.
• W1569478460 cites W2161314639 @default.
• W1569478460 cites W2168007569 @default.
• W1569478460 doi "https://doi.org/10.1046/j.1471-4159.2001.00520.x" @default.
• W1569478460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11595755" @default.
• W1569478460 hasPublicationYear "2008" @default.
• W1569478460 type Work @default.
• W1569478460 sameAs 1569478460 @default.
• W1569478460 citedByCount "89" @default.
• W1569478460 countsByYear W15694784602012 @default.
• W1569478460 countsByYear W15694784602013 @default.
• W1569478460 countsByYear W15694784602014 @default.
• W1569478460 countsByYear W15694784602015 @default.
• W1569478460 countsByYear W15694784602016 @default.
• W1569478460 countsByYear W15694784602017 @default.
• W1569478460 countsByYear W15694784602018 @default.
• W1569478460 countsByYear W15694784602019 @default.
• W1569478460 countsByYear W15694784602020 @default.
• W1569478460 countsByYear W15694784602022 @default.
• W1569478460 countsByYear W15694784602023 @default.
• W1569478460 crossrefType "journal-article" @default.
• W1569478460 hasAuthorship W1569478460A5009193297 @default.
• W1569478460 hasAuthorship W1569478460A5027608139 @default.
• W1569478460 hasAuthorship W1569478460A5079043204 @default.
• W1569478460 hasBestOaLocation W15694784601 @default.
• W1569478460 hasConcept C104317684 @default.
• W1569478460 hasConcept C132149769 @default.
• W1569478460 hasConcept C134018914 @default.
• W1569478460 hasConcept C153911025 @default.
• W1569478460 hasConcept C1629964 @default.
• W1569478460 hasConcept C170493617 @default.
• W1569478460 hasConcept C184235292 @default.
• W1569478460 hasConcept C2776151105 @default.
• W1569478460 hasConcept C2777515746 @default.
• W1569478460 hasConcept C2777542381 @default.
• W1569478460 hasConcept C2777803847 @default.
• W1569478460 hasConcept C2781063702 @default.
• W1569478460 hasConcept C51551487 @default.
• W1569478460 hasConcept C529278444 @default.
• W1569478460 hasConcept C55493867 @default.
• W1569478460 hasConcept C57074206 @default.
• W1569478460 hasConcept C86339819 @default.
• W1569478460 hasConcept C86803240 @default.
• W1569478460 hasConcept C95444343 @default.
• W1569478460 hasConceptScore W1569478460C104317684 @default.
• W1569478460 hasConceptScore W1569478460C132149769 @default.
• W1569478460 hasConceptScore W1569478460C134018914 @default.
• W1569478460 hasConceptScore W1569478460C153911025 @default.
• W1569478460 hasConceptScore W1569478460C1629964 @default.
• W1569478460 hasConceptScore W1569478460C170493617 @default.

• next