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- W1569487466 endingPage "53" @default.
- W1569487466 startingPage "35" @default.
- W1569487466 abstract "Bi-directionality is a common feature observed for genomic replication for all three phylogenetic kingdoms: Eubacteria, Archaea, and Eukaryotes. A consequence of bi-directional replication, where the two replication forks initiated at an origin move away from each other, is that the replication termination will occur at positions away from the origin sequence(s). The replication termination processes are therefore physically and mechanistically dissociated from the replication initiation. The replication machinery is a highly processive complex that in short time copies huge numbers of bases while competing for the DNA substrate with histones, transcription factors, and other DNA-binding proteins. Importantly, the replication machinery generally wins out; meanwhile, when converging forks meet termination occurs, thus preventing over-replication and genetic instability. Very different scenarios for the replication termination processes have been described for the three phylogenetic kingdoms. In eubacterial genomes replication termination is site specific, while in archaea and eukaryotes termination is thought to occur randomly within zones where converging replication forks meet. However, a few site-specific replication barrier elements that mediate replication termination have been described in eukaryotes. This review gives an overview about what is known about replication termination, with a focus on these natural site-specific replication termination sites." @default.
- W1569487466 created "2016-06-24" @default.
- W1569487466 creator A5009486054 @default.
- W1569487466 creator A5021395337 @default.
- W1569487466 creator A5027350154 @default.
- W1569487466 creator A5066456023 @default.
- W1569487466 creator A5068946744 @default.
- W1569487466 creator A5082847660 @default.
- W1569487466 date "2009-01-01" @default.
- W1569487466 modified "2023-09-24" @default.
- W1569487466 title "Random and Site-Specific Replication Termination" @default.
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- W1569487466 doi "https://doi.org/10.1007/978-1-60327-815-7_3" @default.