Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569500827> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1569500827 abstract "The objective of the work described was to identify and synthesize a range of biodegradable hypercoiling or hydrophobically associating polymers to mimic natural apoproteins, such as those found in lung surfactant or plasma apolipoproteins. Stirred interfacial polymerization was used to synthesize potentially biodegradable aromatic polyamides (Mw of 12,000-26,000) based on L-Iysine, L-Iysine ethyl ester, L-ornithine and DL-diaminopropionic acid, by reaction with isophthaloyl chloride. A similar technique was used to synthesize aliphatic polyamides based on L-Iysine ethyl ester and either adipoyl chloride or glutaryl chloride resulting in the synthesis of poly(lysine ethyl ester adipamide) [PLETESA] or poly(lysine ethyl ester glutaramide) (Mw of 126,000 and 26,000, respectively). PLETESA was found to be soluble in both polar and non-polar solvents and the hydrophobic/hydrophilic balance could be modified by partial saponification (66-75%) of the ethyl ester side chains. Surface or interfacial tension/pH profiles were used to assess the conformation of both the poly(isophthalamides) and partially saponified PLETESA in aqueous solution. The results demonstrated that a loss of charge from the polymer was accompanied by an initial fall in surface activity, followed by a rise in activity, and ultimately, by polymer precipitation. These observations were explained by a collapse of the polymer chains into non-surface active intramolecular coils, followed by a transition to an amphipathic conformation, and finally to a collapsed hydrophobe. 2-Dimensional NMR analysis of polymer conformation in polar and non-polar solvents revealed intramolecular associations between the hydrophobic groups within partially saponified PLETESA. Unsaponified PLETESA appeared to form a coiled structure in polar solvents where the ethyl ester side chains were contained within the polymer coil. The implications of the secondary structure of PLETESA and potential biomedical applications are discussed." @default.
- W1569500827 created "2016-06-24" @default.
- W1569500827 creator A5062570969 @default.
- W1569500827 date "1994-09-01" @default.
- W1569500827 modified "2023-09-23" @default.
- W1569500827 title "Hypercoiling and hydrophobically associating polymers : interfacial synthesis, surface properties and pharmaceutical applications" @default.
- W1569500827 hasPublicationYear "1994" @default.
- W1569500827 type Work @default.
- W1569500827 sameAs 1569500827 @default.
- W1569500827 citedByCount "0" @default.
- W1569500827 crossrefType "dissertation" @default.
- W1569500827 hasAuthorship W1569500827A5062570969 @default.
- W1569500827 hasConcept C121332964 @default.
- W1569500827 hasConcept C15761196 @default.
- W1569500827 hasConcept C15920480 @default.
- W1569500827 hasConcept C166940927 @default.
- W1569500827 hasConcept C178790620 @default.
- W1569500827 hasConcept C184651966 @default.
- W1569500827 hasConcept C185592680 @default.
- W1569500827 hasConcept C188027245 @default.
- W1569500827 hasConcept C190399342 @default.
- W1569500827 hasConcept C2780861853 @default.
- W1569500827 hasConcept C521977710 @default.
- W1569500827 hasConcept C62520636 @default.
- W1569500827 hasConcept C67407626 @default.
- W1569500827 hasConcept C8892853 @default.
- W1569500827 hasConceptScore W1569500827C121332964 @default.
- W1569500827 hasConceptScore W1569500827C15761196 @default.
- W1569500827 hasConceptScore W1569500827C15920480 @default.
- W1569500827 hasConceptScore W1569500827C166940927 @default.
- W1569500827 hasConceptScore W1569500827C178790620 @default.
- W1569500827 hasConceptScore W1569500827C184651966 @default.
- W1569500827 hasConceptScore W1569500827C185592680 @default.
- W1569500827 hasConceptScore W1569500827C188027245 @default.
- W1569500827 hasConceptScore W1569500827C190399342 @default.
- W1569500827 hasConceptScore W1569500827C2780861853 @default.
- W1569500827 hasConceptScore W1569500827C521977710 @default.
- W1569500827 hasConceptScore W1569500827C62520636 @default.
- W1569500827 hasConceptScore W1569500827C67407626 @default.
- W1569500827 hasConceptScore W1569500827C8892853 @default.
- W1569500827 hasLocation W15695008271 @default.
- W1569500827 hasOpenAccess W1569500827 @default.
- W1569500827 hasPrimaryLocation W15695008271 @default.
- W1569500827 hasRelatedWork W2001470476 @default.
- W1569500827 hasRelatedWork W2007801997 @default.
- W1569500827 hasRelatedWork W2016046416 @default.
- W1569500827 hasRelatedWork W2022276363 @default.
- W1569500827 hasRelatedWork W2028644538 @default.
- W1569500827 hasRelatedWork W2038489007 @default.
- W1569500827 hasRelatedWork W2039864156 @default.
- W1569500827 hasRelatedWork W2043778008 @default.
- W1569500827 hasRelatedWork W2051044540 @default.
- W1569500827 hasRelatedWork W2058503421 @default.
- W1569500827 hasRelatedWork W2058616004 @default.
- W1569500827 hasRelatedWork W2112510036 @default.
- W1569500827 hasRelatedWork W2133371537 @default.
- W1569500827 hasRelatedWork W2155932727 @default.
- W1569500827 hasRelatedWork W2363155660 @default.
- W1569500827 hasRelatedWork W2368716339 @default.
- W1569500827 hasRelatedWork W2379985750 @default.
- W1569500827 hasRelatedWork W2620712746 @default.
- W1569500827 hasRelatedWork W2517231704 @default.
- W1569500827 hasRelatedWork W2837210726 @default.
- W1569500827 isParatext "false" @default.
- W1569500827 isRetracted "false" @default.
- W1569500827 magId "1569500827" @default.
- W1569500827 workType "dissertation" @default.