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• W1569501755 startingPage "279" @default.
• W1569501755 abstract "Publisher Summary Food restriction (FR) extends the life span and slows many aspects of aging in laboratory rodents. In particular, if animals are allowed 25-40% less food than their ad libitum (ADLIB) intake, their life spans are extended by about the same degree in association with a slowed rate of mortality acceleration. At the level of the individual, FR results in a major slowing of “normal aging” processes at molecular, cellular, and organ levels of function and a reduced incidence of numerous specific pathological conditions in tissues throughout the body, for example, end stage kidney disease and tumors. Examination of a wide range of diet compositions shows that the effects of FR are the result of caloric restriction and are not the result of nutritional imbalances, since micronutrients are supplemented in the modern studies. The generalizability of these findings on FR to humans is highly controversial, but may prove to be most pertinent to those with the phenotypes of adult onset diabetes and adiposity. The majority of studies have focused on non-neural tissues and it is not generally known whether FR also causes slowing of a broad range of CNS aging changes. It is clear, however, that FR modifies neuroendocrine functions in young FR rodents that profoundly influence organ-specific functions and metabolism. The chapter illustrates some of these responses of young rodents to FR, which give a basis for proposing mechanisms in the effects of FR on brain aging." @default.
• W1569501755 created "2016-06-24" @default.
• W1569501755 creator A5040267572 @default.
• W1569501755 creator A5058186185 @default.
• W1569501755 date "1997-01-01" @default.
• W1569501755 modified "2023-10-18" @default.
• W1569501755 title "Chapter 10 Food Restriction and Brain Aging" @default.
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