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- W1569502646 abstract "Abstract Human neural stem/precursor cells (hNSC/hNPC) have been targeted for application in a variety of research models and as prospective candidates for cell‐based therapeutic modalities in central nervous system (CNS) disorders. To this end, the successful derivation, expansion, and sustained maintenance of undifferentiated hNSC/hNPC in vitro, as artificial expandable neurogenic micro‐niches, promises a diversity of applications as well as future potential for a variety of experimental paradigms modeling early human neurogenesis, neuronal migration, and neurogenetic disorders, and could also serve as a platform for small‐molecule drug screening in the CNS. Furthermore, hNPC transplants provide an alternative substrate for cellular regeneration and restoration of damaged tissue in neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease. Human somatic neural stem/progenitor cells (NSC/NPC) have been derived from a variety of cadaveric sources and proven engraftable in a cytoarchitecturally appropriate manner into the developing and adult rodent and monkey brain while maintaining both functional and migratory capabilities in pathological models of disease. In the following unit, we describe a new procedure that we have successfully employed to maintain operationally defined human somatic NSC/NPC from developing fetal, pre‐term post‐natal, and adult cadaveric forebrain. Specifically, we outline the detailed methodology for in vitro expansion, long‐term maintenance, manipulation, and transplantation of these multipotent precursors. Curr. Protoc. Stem Cell Biol . 9:2D.3.1‐2D.3.77. © 2009 by John Wiley & Sons, Inc." @default.
- W1569502646 created "2016-06-24" @default.
- W1569502646 creator A5006964440 @default.
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- W1569502646 date "2009-05-01" @default.
- W1569502646 modified "2023-09-22" @default.
- W1569502646 title "Long‐Term Multilayer Adherent Network (MAN) Expansion, Maintenance, and Characterization, Chemical and Genetic Manipulation, and Transplantation of Human Fetal Forebrain Neural Stem Cells" @default.
- W1569502646 cites W101368795 @default.
- W1569502646 cites W127543024 @default.
- W1569502646 cites W1487222554 @default.
- W1569502646 cites W1491898566 @default.
- W1569502646 cites W1493963890 @default.
- W1569502646 cites W1503270785 @default.
- W1569502646 cites W1503727145 @default.
- W1569502646 cites W1508792316 @default.
- W1569502646 cites W1510613202 @default.
- W1569502646 cites W1512235237 @default.
- W1569502646 cites W1515519882 @default.
- W1569502646 cites W1520969765 @default.
- W1569502646 cites W1535609862 @default.
- W1569502646 cites W1543151032 @default.
- W1569502646 cites W1555449469 @default.
- W1569502646 cites W1562967551 @default.
- W1569502646 cites W1569625891 @default.
- W1569502646 cites W1576773659 @default.
- W1569502646 cites W1576965396 @default.
- W1569502646 cites W1592283056 @default.
- W1569502646 cites W1595834812 @default.
- W1569502646 cites W1606391227 @default.
- W1569502646 cites W1620986627 @default.
- W1569502646 cites W1643680178 @default.
- W1569502646 cites W1733539716 @default.
- W1569502646 cites W1760682360 @default.
- W1569502646 cites W1763750158 @default.
- W1569502646 cites W1834737933 @default.
- W1569502646 cites W1859089489 @default.
- W1569502646 cites W1859730138 @default.
- W1569502646 cites W1875709550 @default.
- W1569502646 cites W1936342032 @default.
- W1569502646 cites W1942092758 @default.
- W1569502646 cites W1963652700 @default.
- W1569502646 cites W1963724707 @default.
- W1569502646 cites W1964032592 @default.
- W1569502646 cites W1964136810 @default.
- W1569502646 cites W1964451213 @default.
- W1569502646 cites W1964903009 @default.
- W1569502646 cites W1965149143 @default.
- W1569502646 cites W1966009759 @default.
- W1569502646 cites W1966653793 @default.
- W1569502646 cites W1967224529 @default.
- W1569502646 cites W1968840425 @default.
- W1569502646 cites W1969225564 @default.
- W1569502646 cites W1970511900 @default.
- W1569502646 cites W1972022525 @default.
- W1569502646 cites W1972409482 @default.
- W1569502646 cites W1972456044 @default.
- W1569502646 cites W1972621208 @default.
- W1569502646 cites W1972651024 @default.
- W1569502646 cites W1972856118 @default.
- W1569502646 cites W1973404900 @default.
- W1569502646 cites W1973647216 @default.
- W1569502646 cites W1973712296 @default.
- W1569502646 cites W1974208182 @default.
- W1569502646 cites W1974338408 @default.
- W1569502646 cites W1974642741 @default.
- W1569502646 cites W1974932537 @default.
- W1569502646 cites W1975066377 @default.
- W1569502646 cites W1975622977 @default.
- W1569502646 cites W1975933612 @default.
- W1569502646 cites W1976034985 @default.
- W1569502646 cites W1976721556 @default.
- W1569502646 cites W1976824219 @default.
- W1569502646 cites W1977364772 @default.
- W1569502646 cites W1977388644 @default.
- W1569502646 cites W1977530922 @default.
- W1569502646 cites W1977907679 @default.
- W1569502646 cites W1978173381 @default.
- W1569502646 cites W1978286697 @default.
- W1569502646 cites W1978607952 @default.
- W1569502646 cites W1978760028 @default.
- W1569502646 cites W1979612418 @default.
- W1569502646 cites W1979895839 @default.
- W1569502646 cites W1979964850 @default.
- W1569502646 cites W1980286364 @default.
- W1569502646 cites W1980441719 @default.
- W1569502646 cites W1980499453 @default.
- W1569502646 cites W1980940171 @default.
- W1569502646 cites W1981220149 @default.
- W1569502646 cites W1981390215 @default.
- W1569502646 cites W1982850249 @default.
- W1569502646 cites W1983668830 @default.
- W1569502646 cites W1983725263 @default.
- W1569502646 cites W1983955843 @default.
- W1569502646 cites W1984112963 @default.
- W1569502646 cites W1984412074 @default.
- W1569502646 cites W1984637659 @default.
- W1569502646 cites W1985244709 @default.