Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569504000> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1569504000 endingPage "5807" @default.
- W1569504000 startingPage "5804" @default.
- W1569504000 abstract "Abstract A particulate preparation from embryonic chicken brain was previously described that catalyzed the transfer of sialic acid from CMP-N-acetylneuraminic acid to galactosyl → glucosyl → ceramide to give a monosialoganglioside, sialyl → galactosyl → glucosyl → ceramide (Reaction A). In the present studies, two monosialogangliosides served as acceptors in similar reactions, giving the corresponding disialogangliosides (Reactions B and C). Reaction B yields the major disialoganglioside of human brain; the acceptor is a ceramide-pentasaccharide containing a terminal galactose residue, and the sialic acid is transferred to this galactose unit. Reaction C involves the synthesis of N-acetylneuraminyl → N-glycolylneuraminyl → galactosyl → glucosyl → ceramide, where the terminal sialic acid is linked at C-8 to the N-glycolylneuraminic acid. The sialyl → sialyl unit occurs in brain tri- and tetrasialogangliosides, and in the minor disialogangliosides. Reaction B represents the last step in the synthesis of the major disialogangliosides from ceramide according to a proposed pathway, while Reaction C represents a branch in the pathway, and may be a key step in the synthesis of the minor disialogangliosides, and of the tri- and tetrasialogangliosides. Kinetic studies indicate that Reactions A, B, and C are catalyzed by different sialyltransferases in the particulate fraction." @default.
- W1569504000 created "2016-06-24" @default.
- W1569504000 creator A5031320059 @default.
- W1569504000 creator A5037131314 @default.
- W1569504000 creator A5065768617 @default.
- W1569504000 date "1968-11-01" @default.
- W1569504000 modified "2023-10-12" @default.
- W1569504000 title "Enzymatic Synthesis of Disialogangliosides from Monosialogangliosides by Sialyltransferases from Embryonic Chicken Brain" @default.
- W1569504000 cites W1555026145 @default.
- W1569504000 cites W1577746592 @default.
- W1569504000 cites W1580023435 @default.
- W1569504000 cites W1672414975 @default.
- W1569504000 cites W1976429449 @default.
- W1569504000 cites W1988517902 @default.
- W1569504000 cites W2006419385 @default.
- W1569504000 cites W2065548762 @default.
- W1569504000 cites W2102129409 @default.
- W1569504000 cites W2168526937 @default.
- W1569504000 cites W2463822735 @default.
- W1569504000 cites W2587827722 @default.
- W1569504000 cites W4232679028 @default.
- W1569504000 cites W982669008 @default.
- W1569504000 doi "https://doi.org/10.1016/s0021-9258(18)91936-8" @default.
- W1569504000 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5699064" @default.
- W1569504000 hasPublicationYear "1968" @default.
- W1569504000 type Work @default.
- W1569504000 sameAs 1569504000 @default.
- W1569504000 citedByCount "156" @default.
- W1569504000 countsByYear W15695040002012 @default.
- W1569504000 countsByYear W15695040002013 @default.
- W1569504000 countsByYear W15695040002014 @default.
- W1569504000 countsByYear W15695040002018 @default.
- W1569504000 countsByYear W15695040002022 @default.
- W1569504000 crossrefType "journal-article" @default.
- W1569504000 hasAuthorship W1569504000A5031320059 @default.
- W1569504000 hasAuthorship W1569504000A5037131314 @default.
- W1569504000 hasAuthorship W1569504000A5065768617 @default.
- W1569504000 hasBestOaLocation W15695040001 @default.
- W1569504000 hasConcept C104317684 @default.
- W1569504000 hasConcept C145103041 @default.
- W1569504000 hasConcept C181199279 @default.
- W1569504000 hasConcept C185592680 @default.
- W1569504000 hasConcept C55493867 @default.
- W1569504000 hasConcept C86803240 @default.
- W1569504000 hasConcept C95444343 @default.
- W1569504000 hasConceptScore W1569504000C104317684 @default.
- W1569504000 hasConceptScore W1569504000C145103041 @default.
- W1569504000 hasConceptScore W1569504000C181199279 @default.
- W1569504000 hasConceptScore W1569504000C185592680 @default.
- W1569504000 hasConceptScore W1569504000C55493867 @default.
- W1569504000 hasConceptScore W1569504000C86803240 @default.
- W1569504000 hasConceptScore W1569504000C95444343 @default.
- W1569504000 hasIssue "21" @default.
- W1569504000 hasLocation W15695040001 @default.
- W1569504000 hasOpenAccess W1569504000 @default.
- W1569504000 hasPrimaryLocation W15695040001 @default.
- W1569504000 hasRelatedWork W1641042124 @default.
- W1569504000 hasRelatedWork W1990804418 @default.
- W1569504000 hasRelatedWork W1993764875 @default.
- W1569504000 hasRelatedWork W2013243191 @default.
- W1569504000 hasRelatedWork W2051339581 @default.
- W1569504000 hasRelatedWork W2082860237 @default.
- W1569504000 hasRelatedWork W2117258802 @default.
- W1569504000 hasRelatedWork W2130076355 @default.
- W1569504000 hasRelatedWork W2151865869 @default.
- W1569504000 hasRelatedWork W4234157524 @default.
- W1569504000 hasVolume "243" @default.
- W1569504000 isParatext "false" @default.
- W1569504000 isRetracted "false" @default.
- W1569504000 magId "1569504000" @default.
- W1569504000 workType "article" @default.