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- W1569504995 abstract "When studying neoplastic cells, a constitutional abnormality may be detected. In this case, it is important to distinguish whether the abnormality present is truly constitutional or an acquired abnormality associated with disease. To make this distinction, a peripheral blood specimen studied for routine chromosome abnormalities is necessary. A listing of the common constitutional chromosome changes is given in this chapter. Sex chromosome aneuploidies are commonly observed among aging females and males in the population. Aneuploidy of the X chromosome, either loss or gain, in 10% or less in females is thought to be an age- related phenomenon and cannot be assumed to be an acquired change associated with hematological disease. Cases with no growth in culture yielding no analyzable metaphases, or very poor growth leading to few metaphases to analyze, are seen in a portion of specimens of any cell type." @default.
- W1569504995 created "2016-06-24" @default.
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- W1569504995 date "2014-08-22" @default.
- W1569504995 modified "2023-10-16" @default.
- W1569504995 title "Results with constitutional or other non‐neoplastic abnormalities" @default.
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- W1569504995 doi "https://doi.org/10.1002/9781118412602.ch21" @default.
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