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- W1569505105 abstract "Allergic diseases are described as immunological conditions characterized by an increased synthesis of IgE with a predominance of Th2 cells over Th1 cells. Consumption of food containing microorganisms is encouraged to restore the imbalance of Th 1 and Th2 cells. The objective of this study is to evaluate immunomodulatory effects of some strains among Leuconostoc citrum (LC) species isolated from Kimchi, a traditional Korean fermented food. After screening, we chose LC 61 and LC 64, which were identified and designated by our laboratory, for their ability to induce strong responses in tumor necrosis factor-alpha and interleukin (IL)-12 secretion by mouse peritoneal macrophages. When mouse splenocytes were incubated with these strains under the Th2 polarizing conditions in which anti-CD3 antibody and recombinant IL-4 were added into the culture media, a six to seven fold higher level of interferon (IFN)-gammaγwas observed but with little effect on IL-4. Further, we examined the ability of LC 61 to regulate the aberrant Th2 response in vivo using the ovalbumin (OVA)-induced allergy model. Oral feeding began 2 weeks before the sensitization and challenge of OVA and continued throughout the experimental period. Mice fed LC 61 showed a reduced level of total IgE, but not OVA-specific IgE, in serum. CD40 (+) cells in the spleen from LC treated mice increased but there was no change in the population of CD4(+), CD8(+), and CD19(+) cells, indicating that LC 61 favored antigen presenting cells that belong to innate immunity. Of note, LC 61 significantly increased the population of CD19(+)CD80(-) cells accompanied by a decrease in the population of CD19(+)CD80(+) cells. Upon OVA restimulation, splenocytes from LC 61 treated mice showed increased levels of IFN-gammaγand IL-4. From our results, the anti-allergic effect of LC 61 seems to be mediated by the suppression of bystander B cell, and possibly T cell too, activation required for IgE synthesis, not by the modulation of allergen-specific responses. We provide evidence that LC 61 isolated from Kimchi can be a beneficial probiotic strain for restoring the dysregulated Th1 and Th2 immune responses." @default.
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- W1569505105 date "2014-04-01" @default.
- W1569505105 modified "2023-09-27" @default.
- W1569505105 title "Leuconostoc citreum 61 isolated from Kimchi, a Korean traditional food, decreases IgE synthesis via suppression of non‐antigen‐specific B cell responses (LB353)" @default.
- W1569505105 doi "https://doi.org/10.1096/fasebj.28.1_supplement.lb353" @default.
- W1569505105 hasPublicationYear "2014" @default.
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