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- W1569517961 abstract "Five experiments were conducted to study the effects of inhibiting growth of an implanted fibrosarcoma in randomly bred and inbred Irish gray rats by (1) adding essential fats to otherwise ineffective diets, and by (2) giving intraperitoneal injections of guinea pig serum. Statistical analysis revealed that cottonseed oil in the diet, without guinea pig serum injections, had significant effects in (1) reducing the number of tumor “takes,” (2) slowing tumor growth or (3) bringing about regressions, unless the tumor was too rapidly growing to allow sufficient time for the production of possible immunologic inhibitory agents. Considering all experiments together the results were significant at the 5% level. Guinea pig serum injections greatly enhanced the effect of fat in the diet, statistically significant at less than 0.01 or less than 0.001 level, except in experiment 2, in which only one series of injections was given. Fat in the diet increased the activity of guinea pig serum injections significantly. The final conclusion must be reached that essential fatty acids are necessary for the fullest resistance of rats to this tumor." @default.
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- W1569517961 date "1959-03-01" @default.
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- W1569517961 title "Studies on the Inhibition of Growth of an Implanted Fibrosarcoma in Rats" @default.
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- W1569517961 doi "https://doi.org/10.1093/jn/67.3.469" @default.
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