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• W1569573716 abstract "Abstract Microdialysis offers many attributes that make it extremely popular as a technique for sampling the extracellular space in the brain of living animals. Correlating the chemical composition of the extracellular space with behavioral events, pharmacological responses, and brain pathophysiology is a central objective in the field of neurochemistry. Microdialysis has evolved to a position of prominence in efforts to achieve this objective. Nonetheless, questions remain unanswered about the relationship between concentrations as measured by microdialysis and the actual in vivo concentration of target substances in the extracellular space of brain tissue. These questions remain open because it is the case that methods for the in vivo calibration of microdialysis probes are not available and are difficult to envision. Although a technique called quantitative microdialysis, based on the determination of no-net-flux concentrations, has been developed, it actually only provides quantitative information when two key parameters, the extraction fraction and relative recovery, of the target substance are the same during the microdialysis procedure. Although quantitative microdialysis has been applied to dopamine, voltammetric recordings of extracellular dopamine in the tissue adjacent to microdialysis probes caste doubt on the idea that the dopamine extraction fraction and relative recovery are equal to each other. This chapter reviews the quantitative basis of in vivo microdialysis, describes the evidence that suggests a difference between the in vivo extraction fraction and relative recovery of dopamine, and considers the consequences of that difference in terms of the nature of the relationship between dopamine as measured by microdialysis and the actual in vivo concentration of dopamine in the brain extracellular space." @default.
• W1569573716 created "2016-06-24" @default.
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• W1569573716 date "2006-01-01" @default.
• W1569573716 modified "2023-09-25" @default.
• W1569573716 title "Chapter 1.6 Quantitative aspects of brain microdialysis: insights from voltammetric measurements of dopamine next to microdialysis probes" @default.
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• W1569573716 doi "https://doi.org/10.1016/s1569-7339(06)16006-3" @default.
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