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- W1569574822 endingPage "595" @default.
- W1569574822 startingPage "539" @default.
- W1569574822 abstract "The purpose of this chapter is to discuss enzyme-ligand interactions. Most physiological and pharmacological responses are mediated by specific receptor-ligand interactions. These receptors are macromolecules specialized in recognizing a specific molecular pattern from the large number of surrounding molecular species with which they could interact, the term “receptor” being used to designate pharmacological receptors, enzymes, antibodies and DNA. The major aspects that determine a biomolecular recognition event, all of them involving changes in both entropy and enthalpy, are: (1) the structural and energetic complementarity between the ligand and the receptor, (2) the conformational rearrangements both structures undergo upon complexation, (3) their desolvation, and (4) the loss of rotational and translational freedom of the ligand when it binds to the active site. The difficulty lies in quantitate and scale the relative contributions of those aspects to the free energy of binding (hence, predicting the affinity)." @default.
- W1569574822 created "2016-06-24" @default.
- W1569574822 creator A5010550163 @default.
- W1569574822 creator A5030034792 @default.
- W1569574822 creator A5080280178 @default.
- W1569574822 date "2001-01-01" @default.
- W1569574822 modified "2023-10-04" @default.
- W1569574822 title "MODELLING ENZYME - LIGAND INTERACTIONS" @default.
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