FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569581473> ?p ?o ?g. }

• W1569581473 endingPage "7" @default.
• W1569581473 startingPage "5312" @default.
• W1569581473 abstract "The putative retinoblastoma gene (Rb) is a tumor suppressor gene which is believed to cause retinoblastomas when both alleles are inactivated, leading to lack of the encoded Mr 110,000-116,000 phosphoprotein. Inactivation of the Rb gene has also been found in several other tumor types, including small cell lung cancer (SCLC). Absence of the 4.7 kilobase mRNA has been found to be frequent in SCLC, and it has been reported that the Rb Mr 110,000-116,000 protein product is always absent, even in tumors expressing Rb mRNA. Using Western blotting technique with a monoclonal antibody directed against the Rb protein, we investigated the expression of the Mr 110,000-116,000 Rb protein in SCLC tumors grown as xenografts in nude mice and/or as cell lines. Rb messenger RNA expression was determined by Northern blotting, and gross structural gene alterations were investigated by Southern blotting. Tumors established from 23 patients were studied. Seven of the tumors did not express Rb protein, whereas expression was detectable in 13. Three tumors were not investigated for protein expression. Only two tumors expressed Rb mRNA without detectable Rb protein expression. Gross DNA alterations were found in four tumors, of which only one expressed Rb mRNA. Our results demonstrated frequent absence of Rb mRNA and protein in SCLC, but apparently normal Rb mRNA and protein were both expressed in more than one-half of the tumors." @default.
• W1569581473 created "2016-06-24" @default.
• W1569581473 creator A5023833711 @default.
• W1569581473 creator A5034495088 @default.
• W1569581473 creator A5061562165 @default.
• W1569581473 creator A5076547698 @default.
• W1569581473 creator A5086351009 @default.
• W1569581473 date "1990-09-01" @default.
• W1569581473 modified "2023-09-23" @default.
• W1569581473 title "Abnormalities in structure and expression of the retinoblastoma gene in small cell lung cancer cell lines and xenografts in nude mice." @default.
• W1569581473 cites W1505037861 @default.
• W1569581473 cites W1536906002 @default.
• W1569581473 cites W1580894495 @default.
• W1569581473 cites W1778117100 @default.
• W1569581473 cites W1973103158 @default.
• W1569581473 cites W1977442544 @default.
• W1569581473 cites W1987291286 @default.
• W1569581473 cites W2003481405 @default.
• W1569581473 cites W2013619212 @default.
• W1569581473 cites W2014669590 @default.
• W1569581473 cites W2017602527 @default.
• W1569581473 cites W2034440981 @default.
• W1569581473 cites W2035975217 @default.
• W1569581473 cites W2038500217 @default.
• W1569581473 cites W2040834490 @default.
• W1569581473 cites W2043221208 @default.
• W1569581473 cites W2045553573 @default.
• W1569581473 cites W2050400539 @default.
• W1569581473 cites W2052878543 @default.
• W1569581473 cites W2066980099 @default.
• W1569581473 cites W2068715807 @default.
• W1569581473 cites W2072581924 @default.
• W1569581473 cites W2077858999 @default.
• W1569581473 cites W2082027741 @default.
• W1569581473 cites W2086322317 @default.
• W1569581473 cites W2092885392 @default.
• W1569581473 cites W2099742439 @default.
• W1569581473 cites W2100837269 @default.
• W1569581473 cites W2114738441 @default.
• W1569581473 cites W2128635872 @default.
• W1569581473 cites W2134812217 @default.
• W1569581473 cites W2142800802 @default.
• W1569581473 cites W2150697333 @default.
• W1569581473 cites W2152432521 @default.
• W1569581473 cites W2155009866 @default.
• W1569581473 cites W2293762542 @default.
• W1569581473 cites W2469550498 @default.
• W1569581473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2167152" @default.
• W1569581473 hasPublicationYear "1990" @default.
• W1569581473 type Work @default.
• W1569581473 sameAs 1569581473 @default.
• W1569581473 citedByCount "16" @default.
• W1569581473 countsByYear W15695814732012 @default.
• W1569581473 crossrefType "journal-article" @default.
• W1569581473 hasAuthorship W1569581473A5023833711 @default.
• W1569581473 hasAuthorship W1569581473A5034495088 @default.
• W1569581473 hasAuthorship W1569581473A5061562165 @default.
• W1569581473 hasAuthorship W1569581473A5076547698 @default.
• W1569581473 hasAuthorship W1569581473A5086351009 @default.
• W1569581473 hasConcept C104317684 @default.
• W1569581473 hasConcept C105580179 @default.
• W1569581473 hasConcept C150194340 @default.
• W1569581473 hasConcept C153911025 @default.
• W1569581473 hasConcept C177707886 @default.
• W1569581473 hasConcept C195286587 @default.
• W1569581473 hasConcept C199835354 @default.
• W1569581473 hasConcept C2776062698 @default.
• W1569581473 hasConcept C2776577112 @default.
• W1569581473 hasConcept C2778264664 @default.
• W1569581473 hasConcept C29537977 @default.
• W1569581473 hasConcept C502942594 @default.
• W1569581473 hasConcept C54355233 @default.
• W1569581473 hasConcept C555283112 @default.
• W1569581473 hasConcept C85265743 @default.
• W1569581473 hasConcept C86803240 @default.
• W1569581473 hasConceptScore W1569581473C104317684 @default.
• W1569581473 hasConceptScore W1569581473C105580179 @default.
• W1569581473 hasConceptScore W1569581473C150194340 @default.
• W1569581473 hasConceptScore W1569581473C153911025 @default.
• W1569581473 hasConceptScore W1569581473C177707886 @default.
• W1569581473 hasConceptScore W1569581473C195286587 @default.
• W1569581473 hasConceptScore W1569581473C199835354 @default.
• W1569581473 hasConceptScore W1569581473C2776062698 @default.
• W1569581473 hasConceptScore W1569581473C2776577112 @default.
• W1569581473 hasConceptScore W1569581473C2778264664 @default.
• W1569581473 hasConceptScore W1569581473C29537977 @default.
• W1569581473 hasConceptScore W1569581473C502942594 @default.
• W1569581473 hasConceptScore W1569581473C54355233 @default.
• W1569581473 hasConceptScore W1569581473C555283112 @default.
• W1569581473 hasConceptScore W1569581473C85265743 @default.
• W1569581473 hasConceptScore W1569581473C86803240 @default.
• W1569581473 hasIssue "17" @default.
• W1569581473 hasLocation W15695814731 @default.
• W1569581473 hasOpenAccess W1569581473 @default.
• W1569581473 hasPrimaryLocation W15695814731 @default.
• W1569581473 hasRelatedWork W132176711 @default.
• W1569581473 hasRelatedWork W1513416145 @default.
• W1569581473 hasRelatedWork W1569581473 @default.

• next