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- W1569585227 abstract "This chapter focuses on various methods for the assessment of intracellular bacterial killing and digestion and the mobilization and action of individual anti-microbial agents within professional phagocytes. Essential host defense responses to invading microbes include sequestration of viable organisms to prevent further dissemination and creation of a highly noxious microenvironment to render the targeted microbe non-viable. Professional phagocytes play major roles in these responses. The antimicrobial role of professional phagocytes, especially of macrophages, includes microbial digestion to facilitate disassembly and removal of microbial remnants, down-regulation of the inflammatory response and return of the host to a resting state. Relatively few host antibacterial proteins have actions sufficiently specific to permit product accumulation to serve faithfully as evidence of their interaction with ingested microbes. Prominent among the array of defensive responses mounted by phagocytes is the agonist-dependent generation of reactive oxygen species (ROS) by neutrophils, monocytes, and macrophages. The enzyme responsible for the conversion of molecular oxygen to superoxide anion is a multicomponent complex composed of a heterodimeric membrane protein, flavocytochrome b558, and at least three cytosolic proteins." @default.
- W1569585227 created "2016-06-24" @default.
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- W1569585227 date "2002-01-01" @default.
- W1569585227 modified "2023-10-17" @default.
- W1569585227 title "26 Antimicrobial activity of host cells" @default.
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- W1569585227 doi "https://doi.org/10.1016/s0580-9517(02)31027-4" @default.
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