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• W1569595964 endingPage "4346" @default.
• W1569595964 startingPage "4339" @default.
• W1569595964 abstract "Spleen necrosis virus (SNV) is an amphotropic retrovirus originally isolated from a duck. Although of avian origin, it also replicates on some mammalian cells. SNV-derived retroviral vectors work with high efficiency and have a high potential for various gene transfer applications. However, little is known about the envelope-receptor interactions of this virus. We constructed a series of recombinant envelope proteins to characterize the SU peptide of SNV. We found that, in contrast to the envelope proteins of other retroviruses, truncated envelope proteins of SNV are transported to the cell surface. Surprisingly, particles displaying truncated envelope proteins can still infect cells, although at reduced efficiencies. Furthermore, these proteins can confer partial superinfection interference. Our data suggest that peptides throughout SU are involved in envelope-receptor interactions. To more precisely determine the localization of the main receptor binding domain, point mutations were introduced at certain regions of the SNV SU which are highly conserved among retroviruses belonging to the same receptor interference group. We identified one point mutation in the middle of SU (position 192) which drastically reduced infectivity and strongly reduced the ability to confer superinfection interference. The level of expression was not abolished, and translocation to the cell membrane of the mutant envelope occurred efficiently. This indicates that amino acid 192 may be directly involved in receptor binding." @default.
• W1569595964 created "2016-06-24" @default.
• W1569595964 creator A5002799814 @default.
• W1569595964 creator A5086029009 @default.
• W1569595964 date "1995-07-01" @default.
• W1569595964 modified "2023-10-18" @default.
• W1569595964 title "Mapping of receptor binding domains in the envelope protein of spleen necrosis virus" @default.
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• W1569595964 doi "https://doi.org/10.1128/jvi.69.7.4339-4346.1995" @default.
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