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- W1569626089 abstract "Twenty six new 17-[3,6-dioxa-8-N-(substituted cinnamyol)octanediamino]-17-demethoxygeldanamycins were designed, synthesized and evaluated for their cytotoxicities against the growth of human breast cancer cell line MDA-MB-231 and binding affinities to heat shock protein 90 (Hsp90). Among these derivatives, 17-(3,6-dioxa-8-N-((E)-3-(3,5-dimethoxyphenyl)acrylamido)octanediamino)-17-demethoxygeldanamycin (3u), was identified as the most potent one (IC50 = 1.5 junol/L, K-d = 1.14 mu mol/L). Additionally, influence of substitutions at the cinnamyol group on the bioactivities of this type of Geldanamycin (GA) derivatives was discussed. This study was anticipated to provide reference for the further structure modifications of GA for developing antitumor agents." @default.
- W1569626089 created "2016-06-24" @default.
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- W1569626089 date "2014-01-01" @default.
- W1569626089 modified "2023-10-18" @default.
- W1569626089 title "Synthesis of Novel 17-[3,6-Dioxa-8-N-(substituted cinnamyol)- octanediamino]-17-demethoxygeldanamycin Derivatives" @default.
- W1569626089 doi "https://doi.org/10.6023/cjoc201404036" @default.
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