FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569631805> ?p ?o ?g. }

• W1569631805 endingPage "47" @default.
• W1569631805 startingPage "38" @default.
• W1569631805 abstract "Human lactoferrin (hLF), a member of the transferrin family, is known for its antimicrobial and anti-inflammatory effects. Recent studies on various nonskin cell lines indicate that hLF may have a stimulatory effect on cell proliferation.To study the potential role of hLF in wound re-epithelialization.The effects of hLF on cell growth, migration, attachment and survival were assessed, with a rice-derived recombinant hLF (holo-rhLF), using proliferation analysis, scratch migration assay, calcein-AM/propidium iodide staining and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labelling (TUNEL) method, respectively. The mechanisms of hLF on cell proliferation and migration were explored using specific pathway inhibitors. The involvement of lactoferrin receptor low-density lipoprotein receptor-related protein 1 (LRP1) was examined with RNA interference technique. An in vivo swine second-degree burn wound model was also used to assess wound re-epithelialization.Studies revealed that holo-rhLF significantly stimulated keratinocyte proliferation which could be blocked by mitogen-activated protein kinase (MAPK) kinase 1 inhibitor. Holo-rhLF also showed strong promoting effects on keratinocyte migration, which could be blocked by either inhibition of the MAPK, Src and Rho/ROCK pathways, or downregulation of the LRP1 receptor. With cells under starving or 12-O-tetradecanoylphorbol-13-acetate exposure, the addition of holo-rhLF was found greatly to increase cell viability and inhibit cell apoptosis. Additionally, holo-rhLF significantly increased the rate of wound re-epithelialization in swine second-degree burn wounds.Our studies demonstrate the direct effects of holo-rhLF on wound re-epithelialization including the enhancement of keratinocyte proliferation and migration as well as the protection of cells from apoptosis. The data strongly indicate its potential therapeutic applications in wound healing." @default.
• W1569631805 created "2016-06-24" @default.
• W1569631805 creator A5006561406 @default.
• W1569631805 creator A5030866369 @default.
• W1569631805 creator A5032454817 @default.
• W1569631805 creator A5037506382 @default.
• W1569631805 creator A5037970022 @default.
• W1569631805 creator A5042980538 @default.
• W1569631805 creator A5051623365 @default.
• W1569631805 creator A5062855478 @default.
• W1569631805 creator A5079071766 @default.
• W1569631805 date "2010-03-06" @default.
• W1569631805 modified "2023-10-06" @default.
• W1569631805 title "Human lactoferrin stimulates skin keratinocyte function and wound re-epithelialization" @default.
• W1569631805 cites W1497205269 @default.
• W1569631805 cites W1966012171 @default.
• W1569631805 cites W1967205571 @default.
• W1569631805 cites W1968516468 @default.
• W1569631805 cites W1968826282 @default.
• W1569631805 cites W1968907758 @default.
• W1569631805 cites W1969528561 @default.
• W1569631805 cites W1971266929 @default.
• W1569631805 cites W1975638599 @default.
• W1569631805 cites W1980890016 @default.
• W1569631805 cites W1982516347 @default.
• W1569631805 cites W1986309784 @default.
• W1569631805 cites W1987357828 @default.
• W1569631805 cites W1995649574 @default.
• W1569631805 cites W1996546271 @default.
• W1569631805 cites W1999340744 @default.
• W1569631805 cites W2000728376 @default.
• W1569631805 cites W2013497532 @default.
• W1569631805 cites W2033459667 @default.
• W1569631805 cites W2036381341 @default.
• W1569631805 cites W2043337314 @default.
• W1569631805 cites W2044408827 @default.
• W1569631805 cites W2062909484 @default.
• W1569631805 cites W2068913584 @default.
• W1569631805 cites W2069485141 @default.
• W1569631805 cites W2070995184 @default.
• W1569631805 cites W2071140344 @default.
• W1569631805 cites W2076757257 @default.
• W1569631805 cites W2083094460 @default.
• W1569631805 cites W2083517654 @default.
• W1569631805 cites W2087286937 @default.
• W1569631805 cites W2121453357 @default.
• W1569631805 cites W2137061913 @default.
• W1569631805 cites W2152065348 @default.
• W1569631805 cites W2155496317 @default.
• W1569631805 cites W2169251401 @default.
• W1569631805 cites W2324994433 @default.
• W1569631805 cites W2325727928 @default.
• W1569631805 cites W2415859941 @default.
• W1569631805 doi "https://doi.org/10.1111/j.1365-2133.2010.09748.x" @default.
• W1569631805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20222924" @default.
• W1569631805 hasPublicationYear "2010" @default.
• W1569631805 type Work @default.
• W1569631805 sameAs 1569631805 @default.
• W1569631805 citedByCount "64" @default.
• W1569631805 countsByYear W15696318052012 @default.
• W1569631805 countsByYear W15696318052013 @default.
• W1569631805 countsByYear W15696318052014 @default.
• W1569631805 countsByYear W15696318052015 @default.
• W1569631805 countsByYear W15696318052016 @default.
• W1569631805 countsByYear W15696318052017 @default.
• W1569631805 countsByYear W15696318052018 @default.
• W1569631805 countsByYear W15696318052019 @default.
• W1569631805 countsByYear W15696318052020 @default.
• W1569631805 countsByYear W15696318052021 @default.
• W1569631805 countsByYear W15696318052022 @default.
• W1569631805 countsByYear W15696318052023 @default.
• W1569631805 crossrefType "journal-article" @default.
• W1569631805 hasAuthorship W1569631805A5006561406 @default.
• W1569631805 hasAuthorship W1569631805A5030866369 @default.
• W1569631805 hasAuthorship W1569631805A5032454817 @default.
• W1569631805 hasAuthorship W1569631805A5037506382 @default.
• W1569631805 hasAuthorship W1569631805A5037970022 @default.
• W1569631805 hasAuthorship W1569631805A5042980538 @default.
• W1569631805 hasAuthorship W1569631805A5051623365 @default.
• W1569631805 hasAuthorship W1569631805A5062855478 @default.
• W1569631805 hasAuthorship W1569631805A5079071766 @default.
• W1569631805 hasConcept C118995209 @default.
• W1569631805 hasConcept C137738243 @default.
• W1569631805 hasConcept C139647698 @default.
• W1569631805 hasConcept C1491633281 @default.
• W1569631805 hasConcept C153911025 @default.
• W1569631805 hasConcept C170493617 @default.
• W1569631805 hasConcept C184235292 @default.
• W1569631805 hasConcept C185592680 @default.
• W1569631805 hasConcept C190283241 @default.
• W1569631805 hasConcept C196795494 @default.
• W1569631805 hasConcept C202751555 @default.
• W1569631805 hasConcept C203014093 @default.
• W1569631805 hasConcept C2775934118 @default.
• W1569631805 hasConcept C2775960820 @default.
• W1569631805 hasConcept C2777074287 @default.
• W1569631805 hasConcept C2778163477 @default.
• W1569631805 hasConcept C2778615670 @default.

• next