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• W1569646376 abstract "Eleven patients with a variety of fatal diseases received transplants of allogeneic bone marrow. Transplantation of human leukocyte group A (HL-A) identical marrow to three patients with lymphopenic immunologic deficiency was successful, although one died of a pre-transplant pneumonic process. After transplantation of HL-A nonidentical marrow obtained from his father, one patient with lymphopenic immunologic deficiency died from graft-versus-host disease (GVHD). A patient with chronic mucocutaneous candidiasis had a remission of her disease after bone marrow transplantation with HL-A nonidentical marrow but suffered from chronic diarrhea possibly caused by GVHD. Administration of cyclophosphamide was necessary for the marrow to “take” in patients with functional cellular immunity. One patient had transitory remission of her leukemia after bone marrow transplantation. A patient with grade IVB Hodgkin's disease died, with evidence of bone marrow take and of GVHD despite the fact that donor and recipient were identical at the HL-A locus. Two patients with terminal aplastic anemia died of sepsis shortly after bone marrow transplantation, probably due to a combination of their disease and the administration of cyclophosphamide. HL-A identical marrow failed to take in two patients who had received no preparatory immunosuppressive therapy. Transplantation of HL-A identical bone marrow may be lifesaving and is the treatment of choice in patients with lymphopenic immunologic deficiency (LID). It may be of significant benefit in the treatment of diseases in which cell-mediated immune functions (CMIF) are abnormal. In patients with functional cell-mediated immunity, bone marrow transplantation following severe immunosuppressive therapy may be life-saving, but the dangers of this form of therapy—primarily GVHD and sepsis—are great. Transplantation of HL-A nonidentical marrow is at present very hazardous." @default.
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• W1569646376 date "1971-10-01" @default.
• W1569646376 modified "2023-09-23" @default.
• W1569646376 title "Bone marrow transplantation" @default.
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• W1569646376 doi "https://doi.org/10.1016/0002-9343(71)90257-9" @default.
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