Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569651992> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1569651992 abstract "Prostate cancer is a very important health problem in the UK and worldwide. Available treatments such as radiotherapy, surgery and androgen ablation have failed to significantly increase the life expectancy of prostate cancer patients. Therefore researching new treatments is paramount. A promising approach for prostate cancer is suicide gene therapy. In this work, the use of the NTR/CB1954 enzyme/prodrug system delivered by a baculovirus vector was investigated for its application in prostate cancer cell lines and prostate primary epithelial cultures. The results suggest that the NTR/CB1954 system is highlyefficient in causing cell death in prostate cell lines and prostate primary epithelial cultures. The use of a baculovirus vector to deliver the NTR gene resulted in increased transduction of prostate cancer cell lines in comparison to non-malignant prostate and non-prostate cell lines. To target NTR expression to prostate cells the regulation of the hTGP promoter was dissected. hTGPexpression was confirmed to be highly prostate specific and mainly regulated by retinoic acid, androgens, retinoic acid receptor gamma and the androgen receptor. This work presents the first evidence of an interaction between thesenuclear receptors and challenges the current model for prostate specific expression. Finally a baculovirus encoding the NTR gene under the control of the hTGP promoter was tested in prostate cancer cell lines resulting in moderate cell death. These findings are very encouraging but in order to use the hTGP promoter for gene therapy there needs to be further manipulation of the sequence to optimise its potency while maintaining its prostate specificity. The use of NTR and baculovirus coupled to the targeting controlled provided by the hTGP promoter could develop into a potent and specific approach to treat prostate cancer." @default.
- W1569651992 created "2016-06-24" @default.
- W1569651992 creator A5029615730 @default.
- W1569651992 creator A5055044093 @default.
- W1569651992 date "2011-12-01" @default.
- W1569651992 modified "2023-09-24" @default.
- W1569651992 title "Regulation of the prostate-specific hTGP (TGM4) gene and its potential use for prostate cancer gene therapy" @default.
- W1569651992 hasPublicationYear "2011" @default.
- W1569651992 type Work @default.
- W1569651992 sameAs 1569651992 @default.
- W1569651992 citedByCount "0" @default.
- W1569651992 crossrefType "dissertation" @default.
- W1569651992 hasAuthorship W1569651992A5029615730 @default.
- W1569651992 hasAuthorship W1569651992A5055044093 @default.
- W1569651992 hasConcept C104317684 @default.
- W1569651992 hasConcept C111599444 @default.
- W1569651992 hasConcept C121608353 @default.
- W1569651992 hasConcept C126322002 @default.
- W1569651992 hasConcept C143998085 @default.
- W1569651992 hasConcept C2776235491 @default.
- W1569651992 hasConcept C2780192828 @default.
- W1569651992 hasConcept C34981463 @default.
- W1569651992 hasConcept C502942594 @default.
- W1569651992 hasConcept C54355233 @default.
- W1569651992 hasConcept C61367390 @default.
- W1569651992 hasConcept C71924100 @default.
- W1569651992 hasConcept C86803240 @default.
- W1569651992 hasConceptScore W1569651992C104317684 @default.
- W1569651992 hasConceptScore W1569651992C111599444 @default.
- W1569651992 hasConceptScore W1569651992C121608353 @default.
- W1569651992 hasConceptScore W1569651992C126322002 @default.
- W1569651992 hasConceptScore W1569651992C143998085 @default.
- W1569651992 hasConceptScore W1569651992C2776235491 @default.
- W1569651992 hasConceptScore W1569651992C2780192828 @default.
- W1569651992 hasConceptScore W1569651992C34981463 @default.
- W1569651992 hasConceptScore W1569651992C502942594 @default.
- W1569651992 hasConceptScore W1569651992C54355233 @default.
- W1569651992 hasConceptScore W1569651992C61367390 @default.
- W1569651992 hasConceptScore W1569651992C71924100 @default.
- W1569651992 hasConceptScore W1569651992C86803240 @default.
- W1569651992 hasLocation W15696519921 @default.
- W1569651992 hasOpenAccess W1569651992 @default.
- W1569651992 hasPrimaryLocation W15696519921 @default.
- W1569651992 hasRelatedWork W126960128 @default.
- W1569651992 hasRelatedWork W1571384143 @default.
- W1569651992 hasRelatedWork W2010984112 @default.
- W1569651992 hasRelatedWork W2055979283 @default.
- W1569651992 hasRelatedWork W2075750372 @default.
- W1569651992 hasRelatedWork W2085618049 @default.
- W1569651992 hasRelatedWork W2097585139 @default.
- W1569651992 hasRelatedWork W2103210170 @default.
- W1569651992 hasRelatedWork W2130040381 @default.
- W1569651992 hasRelatedWork W2292372754 @default.
- W1569651992 hasRelatedWork W2411407048 @default.
- W1569651992 hasRelatedWork W2463689612 @default.
- W1569651992 hasRelatedWork W2738998462 @default.
- W1569651992 hasRelatedWork W2771442643 @default.
- W1569651992 hasRelatedWork W2983830863 @default.
- W1569651992 hasRelatedWork W3196855221 @default.
- W1569651992 hasRelatedWork W3208333027 @default.
- W1569651992 hasRelatedWork W2136366759 @default.
- W1569651992 hasRelatedWork W2850074252 @default.
- W1569651992 hasRelatedWork W3110291997 @default.
- W1569651992 isParatext "false" @default.
- W1569651992 isRetracted "false" @default.
- W1569651992 magId "1569651992" @default.
- W1569651992 workType "dissertation" @default.