FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569654311> ?p ?o ?g. }

• W1569654311 abstract "In this paper we study the phenomenon of kinetic partitioning when a polypeptide chain has two ground state conformations one of which is more kinetically reachable than the other. This question is relevant to understand the phenomenology of prions, proteins which exist in the cell in non-pathogenic $alpha$-helical conformation but under certain circumstances may transform into pathogenic $PrP^{Sc}$ state featuring increased $beta$-sheet content. We designed sequences for lattice model proteins having two different conformations of equal energy corresponding to the global energy minimum. Folding simulations revealed that one of these conformations was indeed much more kinetically accessible than the other. We found that the number and strength of local contacts in the ground state conformation is the major factor which determines which conformation is reached faster: The greater the number of local contacts the more kinetically reachable a conformation is. We present simple statistical-mechanical arguments to explain these findings. The presented results are in a clear agreement with experimental data on prions and other proteins exhibiting kinetic partitioning." @default.
• W1569654311 created "2016-06-24" @default.
• W1569654311 creator A5071147112 @default.
• W1569654311 creator A5082765817 @default.
• W1569654311 creator A5089469355 @default.
• W1569654311 date "1996-06-25" @default.
• W1569654311 modified "2023-09-27" @default.
• W1569654311 title "Theory of Kinetic Partitioning in Protein Folding (With Application to Prions)" @default.
• W1569654311 cites W1501494207 @default.
• W1569654311 cites W1550166367 @default.
• W1569654311 cites W1571398079 @default.
• W1569654311 cites W1598577877 @default.
• W1569654311 cites W1601881612 @default.
• W1569654311 cites W1975017420 @default.
• W1569654311 cites W1978335878 @default.
• W1569654311 cites W1988690429 @default.
• W1569654311 cites W1989300794 @default.
• W1569654311 cites W1989373400 @default.
• W1569654311 cites W1992084965 @default.
• W1569654311 cites W2003604086 @default.
• W1569654311 cites W2005865331 @default.
• W1569654311 cites W2008713184 @default.
• W1569654311 cites W2016019576 @default.
• W1569654311 cites W2033752086 @default.
• W1569654311 cites W2034359525 @default.
• W1569654311 cites W2047052655 @default.
• W1569654311 cites W2053187744 @default.
• W1569654311 cites W2057591350 @default.
• W1569654311 cites W2061346634 @default.
• W1569654311 cites W2065310894 @default.
• W1569654311 cites W2072244190 @default.
• W1569654311 cites W2072843928 @default.
• W1569654311 cites W2077990003 @default.
• W1569654311 cites W2078067862 @default.
• W1569654311 cites W2089206424 @default.
• W1569654311 cites W2097246107 @default.
• W1569654311 cites W2101366028 @default.
• W1569654311 cites W2146606022 @default.
• W1569654311 cites W2167503783 @default.
• W1569654311 cites W2011495938 @default.
• W1569654311 hasPublicationYear "1996" @default.
• W1569654311 type Work @default.
• W1569654311 sameAs 1569654311 @default.
• W1569654311 citedByCount "0" @default.
• W1569654311 crossrefType "posted-content" @default.
• W1569654311 hasAuthorship W1569654311A5071147112 @default.
• W1569654311 hasAuthorship W1569654311A5082765817 @default.
• W1569654311 hasAuthorship W1569654311A5089469355 @default.
• W1569654311 hasConcept C119599485 @default.
• W1569654311 hasConcept C121332964 @default.
• W1569654311 hasConcept C121864883 @default.
• W1569654311 hasConcept C127413603 @default.
• W1569654311 hasConcept C135889238 @default.
• W1569654311 hasConcept C159467904 @default.
• W1569654311 hasConcept C185592680 @default.
• W1569654311 hasConcept C204328495 @default.
• W1569654311 hasConcept C24890656 @default.
• W1569654311 hasConcept C2776545253 @default.
• W1569654311 hasConcept C2781204021 @default.
• W1569654311 hasConcept C55493867 @default.
• W1569654311 hasConcept C62520636 @default.
• W1569654311 hasConcept C69523127 @default.
• W1569654311 hasConcept C74650414 @default.
• W1569654311 hasConcept C8010536 @default.
• W1569654311 hasConceptScore W1569654311C119599485 @default.
• W1569654311 hasConceptScore W1569654311C121332964 @default.
• W1569654311 hasConceptScore W1569654311C121864883 @default.
• W1569654311 hasConceptScore W1569654311C127413603 @default.
• W1569654311 hasConceptScore W1569654311C135889238 @default.
• W1569654311 hasConceptScore W1569654311C159467904 @default.
• W1569654311 hasConceptScore W1569654311C185592680 @default.
• W1569654311 hasConceptScore W1569654311C204328495 @default.
• W1569654311 hasConceptScore W1569654311C24890656 @default.
• W1569654311 hasConceptScore W1569654311C2776545253 @default.
• W1569654311 hasConceptScore W1569654311C2781204021 @default.
• W1569654311 hasConceptScore W1569654311C55493867 @default.
• W1569654311 hasConceptScore W1569654311C62520636 @default.
• W1569654311 hasConceptScore W1569654311C69523127 @default.
• W1569654311 hasConceptScore W1569654311C74650414 @default.
• W1569654311 hasConceptScore W1569654311C8010536 @default.
• W1569654311 hasLocation W15696543111 @default.
• W1569654311 hasOpenAccess W1569654311 @default.
• W1569654311 hasPrimaryLocation W15696543111 @default.
• W1569654311 hasRelatedWork W1512919934 @default.
• W1569654311 hasRelatedWork W1639593376 @default.
• W1569654311 hasRelatedWork W166887480 @default.
• W1569654311 hasRelatedWork W1985530920 @default.
• W1569654311 hasRelatedWork W1989897388 @default.
• W1569654311 hasRelatedWork W2003604086 @default.
• W1569654311 hasRelatedWork W2009467983 @default.
• W1569654311 hasRelatedWork W2022876748 @default.
• W1569654311 hasRelatedWork W2025142768 @default.
• W1569654311 hasRelatedWork W2056870055 @default.
• W1569654311 hasRelatedWork W2057820165 @default.
• W1569654311 hasRelatedWork W2065363454 @default.
• W1569654311 hasRelatedWork W2066370108 @default.
• W1569654311 hasRelatedWork W2067441096 @default.
• W1569654311 hasRelatedWork W2073403131 @default.
• W1569654311 hasRelatedWork W2091107331 @default.
• W1569654311 hasRelatedWork W2101366028 @default.

• next