FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569668463> ?p ?o ?g. }

• W1569668463 endingPage "420" @default.
• W1569668463 startingPage "401" @default.
• W1569668463 abstract "Publisher Summary Ribozymes represent a relatively new approach for specific inactivation of gene expression. To date, ribozymes have been reported to be effective in cell culture against a variety of RNA targets, including viral, endogenous, and transfected sequences. Ribozymes have been utilized to functionally destroy mRNAs as well as for the repair of mutant RNAs. These RNA catalysts have progressed to the stage where both hammerhead and hairpin ribozymes are currently being tested in human clinical trials. The effective use of ribozymes in vivo depends on effective target-site selection, knowledge of the rules governing intracellular localization, effective delivery to target cells, and maintaining a high and long-term intracellular expression of the engineered gene. Over the past decade, ribozymes have been widely employed in a variety of systems. Their use as tools to control gene expression is both enticing and simple in concept. Ribozymes can be designed to specifically base pair with and cleave any given RNA target, with the result of producing an irreversible inactivation of the targeted RNA. Because these catalytic RNAs can be designed to have exquisite specificity and are inherently devoid of coding capacities, there is little likelihood for undesired cellular toxicities. The combination of specificity, the possibilities of endogeneous synthesis or exogenous delivery, and the capability to be adapted for the destruction or modification of any RNA species make ribozymes extremely attractive genetic tools and potential therapeutic agents. The major limitations to effective intracellular ribozyme use are colocalization of ribozymes with target RNAs and target-site accessibility. These specific problems are discussed in this chapter. In addition, strategies and protocols for expression and delivery of ribozyme genes are addressed." @default.
• W1569668463 created "2016-06-24" @default.
• W1569668463 creator A5000286275 @default.
• W1569668463 creator A5001187257 @default.
• W1569668463 creator A5046038634 @default.
• W1569668463 date "2000-01-01" @default.
• W1569668463 modified "2023-10-16" @default.
• W1569668463 title "Intracellular expression and function of antisense catalytic RNAs" @default.
• W1569668463 cites W1184825705 @default.
• W1569668463 cites W1507488072 @default.
• W1569668463 cites W1509315828 @default.
• W1569668463 cites W1511818607 @default.
• W1569668463 cites W1522226780 @default.
• W1569668463 cites W1646843515 @default.
• W1569668463 cites W1686812758 @default.
• W1569668463 cites W1784969882 @default.
• W1569668463 cites W1832209337 @default.
• W1569668463 cites W1832452463 @default.
• W1569668463 cites W1881326155 @default.
• W1569668463 cites W1905106889 @default.
• W1569668463 cites W1964553785 @default.
• W1569668463 cites W1974714573 @default.
• W1569668463 cites W1979320661 @default.
• W1569668463 cites W1980527259 @default.
• W1569668463 cites W1983287256 @default.
• W1569668463 cites W1987101891 @default.
• W1569668463 cites W1990967581 @default.
• W1569668463 cites W1993996978 @default.
• W1569668463 cites W1996026980 @default.
• W1569668463 cites W1996245771 @default.
• W1569668463 cites W2002048308 @default.
• W1569668463 cites W2015243129 @default.
• W1569668463 cites W2015671015 @default.
• W1569668463 cites W2018117114 @default.
• W1569668463 cites W2020887273 @default.
• W1569668463 cites W2025116940 @default.
• W1569668463 cites W2031829988 @default.
• W1569668463 cites W2033282111 @default.
• W1569668463 cites W2036960084 @default.
• W1569668463 cites W2037702309 @default.
• W1569668463 cites W2040029402 @default.
• W1569668463 cites W2041331047 @default.
• W1569668463 cites W2043886388 @default.
• W1569668463 cites W2047651351 @default.
• W1569668463 cites W2051403136 @default.
• W1569668463 cites W2071601231 @default.
• W1569668463 cites W2075721485 @default.
• W1569668463 cites W2076857736 @default.
• W1569668463 cites W2080036688 @default.
• W1569668463 cites W2083929510 @default.
• W1569668463 cites W2085389882 @default.
• W1569668463 cites W2089111392 @default.
• W1569668463 cites W2094601780 @default.
• W1569668463 cites W2095787255 @default.
• W1569668463 cites W2115066994 @default.
• W1569668463 cites W2124077526 @default.
• W1569668463 cites W2131286935 @default.
• W1569668463 cites W2134816300 @default.
• W1569668463 cites W2138403036 @default.
• W1569668463 cites W2145899011 @default.
• W1569668463 cites W2158254083 @default.
• W1569668463 cites W2162162459 @default.
• W1569668463 cites W2163414819 @default.
• W1569668463 cites W2165041268 @default.
• W1569668463 cites W2262545252 @default.
• W1569668463 cites W4212787727 @default.
• W1569668463 cites W4256466569 @default.
• W1569668463 cites W4256704256 @default.
• W1569668463 cites W52968187 @default.
• W1569668463 doi "https://doi.org/10.1016/s0076-6879(00)13025-3" @default.
• W1569668463 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10595369" @default.
• W1569668463 hasPublicationYear "2000" @default.
• W1569668463 type Work @default.
• W1569668463 sameAs 1569668463 @default.
• W1569668463 citedByCount "19" @default.
• W1569668463 crossrefType "book-chapter" @default.
• W1569668463 hasAuthorship W1569668463A5000286275 @default.
• W1569668463 hasAuthorship W1569668463A5001187257 @default.
• W1569668463 hasAuthorship W1569668463A5046038634 @default.
• W1569668463 hasConcept C104317684 @default.
• W1569668463 hasConcept C14036430 @default.
• W1569668463 hasConcept C150194340 @default.
• W1569668463 hasConcept C185592680 @default.
• W1569668463 hasConcept C199360897 @default.
• W1569668463 hasConcept C202416437 @default.
• W1569668463 hasConcept C41008148 @default.
• W1569668463 hasConcept C55493867 @default.
• W1569668463 hasConcept C79879829 @default.
• W1569668463 hasConcept C86803240 @default.
• W1569668463 hasConcept C90559484 @default.
• W1569668463 hasConcept C95444343 @default.
• W1569668463 hasConceptScore W1569668463C104317684 @default.
• W1569668463 hasConceptScore W1569668463C14036430 @default.
• W1569668463 hasConceptScore W1569668463C150194340 @default.
• W1569668463 hasConceptScore W1569668463C185592680 @default.
• W1569668463 hasConceptScore W1569668463C199360897 @default.
• W1569668463 hasConceptScore W1569668463C202416437 @default.
• W1569668463 hasConceptScore W1569668463C41008148 @default.

• next