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- W1569669219 abstract "Good and his colleagues have suggested that vertebrate immunity may have evolved into a two-component system: a thymus-dependent component primarily regulating cellular immunity, and a bursal-dependent system primarily regulating humoral immunity. These workers proposed that such structures as the tonsils, appendix and Peyer9s patches may be the primary or central mammalian analogue of the avian bursa of Fabricius, whose removal causes ablation of humoral antibody responses in birds. They found that extirpation of gut-associated lymphoepithelial tissue in rabbits, followed by irradiation, produced deficiencies of specific antibody and immunoglobulin formation (1–3). We have been interested in defining a possible role for Peyer9s patches in humoral immunity. We studied first the immune response of spleen and Peyer9s patch cells in 1-month-old C57BL/6 mice stimulated with intraperitoneal (i.p.) injections of 2.5 × 10 8 sheep red blood cells (SRBC)." @default.
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- W1569669219 date "1972-03-01" @default.
- W1569669219 modified "2023-09-23" @default.
- W1569669219 title "Synergism between Peyer's patch cells and spleen cells in humoral antibody production." @default.
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