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- W1569678259 abstract "Publisher Summary This chapter describes the assays of omeprazole metabolism as a substrate probe for human CYP isoforms. Omeprazole, a substituted benzimidazole inhibitor of the gastric proton pump H + , K + -ATPase, is essentially completely metabolized in vivo . The major metabolites detected in blood in vivo are omeprazole sulfone and hydroxyomeprazole. The major urinary metabolites identified are hydroxyomeprazole and its corresponding carboxylic acid, with neither omeprazole itself nor omeprazole sulfone being detected. Hydroxyomeprazole is converted into carboxylic acid by cytosolic alcohol and aldehyde dehydrogenases, and omeprazole sulfone is essentially completely further metabolized. Omeprazole is an effective substrate for both CYP2C19 and CYP3A4, but different metabolites are formed by the two isoforms. Hydroxyomeprazole and omeprazole sulfone show similar CYP specificity to the parent drug. Sulfone formation is mediated by CYP3A4, and the hydroxy formation is mediated mainly by CYP2C19." @default.
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- W1569678259 date "1996-01-01" @default.
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- W1569678259 title "[14] Assays of omeprazole metabolism as a substrate probe for human CYP isoforms" @default.
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- W1569678259 doi "https://doi.org/10.1016/s0076-6879(96)72016-5" @default.
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