Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569680763> ?p ?o ?g. }
- W1569680763 endingPage "108" @default.
- W1569680763 startingPage "75" @default.
- W1569680763 abstract "This chapter discusses the role of cytoskeleton in genome regulation and cancer. It describes two-tiered theory of regulation of the mammalian genome to the problem of cancer. Cancer represents a distortion of normal metabolic regulation. Cancer cells exhibit a loss of differentiation properties and a concomitant loss of growth control. The phenomenon of reverse transformation offers a unique opportunity to study the molecular nature of cancer. The cancer cells revert to the normal phenotype in the presence of cell-specific agonists and return to their original malignant behavior on its removal. The two-tiered scheme for the regulation of the mammalian genome accounts for the mode of action of genes that are differentiation specific in the mammalian organism. The first step in the activation of such tissue-specific genes is their conversion from the sequestered to the exposed state. This involves transfer of the appropriate DNA from the interior of the nucleus to the region of the nuclear periphery and the necessary conformational changes and specific protein interactions that render such DNA susceptible to hydrolysis by DNase I. The second step, which resembles the corresponding process in bacteria, is activation or inactivation of the exposed genes as a result of interaction with appropriate effector molecules in the surrounding medium. The restoration of cytoskeletal control of nuclear function in reverse transformation allows increased genome exposure and access of DNA to specific transcriptional regulators." @default.
- W1569680763 created "2016-06-24" @default.
- W1569680763 creator A5012843007 @default.
- W1569680763 creator A5067688389 @default.
- W1569680763 date "1992-01-01" @default.
- W1569680763 modified "2023-10-13" @default.
- W1569680763 title "Role of the Cytoskeleton in Genome Regulation and Cancer" @default.
- W1569680763 cites W1187258172 @default.
- W1569680763 cites W1534148261 @default.
- W1569680763 cites W1800027138 @default.
- W1569680763 cites W1926825532 @default.
- W1569680763 cites W1967986618 @default.
- W1569680763 cites W1969023545 @default.
- W1569680763 cites W1970028292 @default.
- W1569680763 cites W1970266617 @default.
- W1569680763 cites W1978917891 @default.
- W1569680763 cites W1982826618 @default.
- W1569680763 cites W1984774455 @default.
- W1569680763 cites W1985478809 @default.
- W1569680763 cites W1985499212 @default.
- W1569680763 cites W1987623343 @default.
- W1569680763 cites W1989575075 @default.
- W1569680763 cites W1990927954 @default.
- W1569680763 cites W1999939543 @default.
- W1569680763 cites W2001027887 @default.
- W1569680763 cites W2004845206 @default.
- W1569680763 cites W2008900071 @default.
- W1569680763 cites W2010585577 @default.
- W1569680763 cites W2015990519 @default.
- W1569680763 cites W2017813247 @default.
- W1569680763 cites W2018983295 @default.
- W1569680763 cites W2020677330 @default.
- W1569680763 cites W2020816450 @default.
- W1569680763 cites W2022975546 @default.
- W1569680763 cites W2027746409 @default.
- W1569680763 cites W2028317903 @default.
- W1569680763 cites W2032384795 @default.
- W1569680763 cites W2033300901 @default.
- W1569680763 cites W2036648250 @default.
- W1569680763 cites W2037565046 @default.
- W1569680763 cites W2039506829 @default.
- W1569680763 cites W2040579328 @default.
- W1569680763 cites W2041936120 @default.
- W1569680763 cites W2044397557 @default.
- W1569680763 cites W2046803531 @default.
- W1569680763 cites W2049698613 @default.
- W1569680763 cites W2052090797 @default.
- W1569680763 cites W2052653077 @default.
- W1569680763 cites W2059851697 @default.
- W1569680763 cites W2062145172 @default.
- W1569680763 cites W2069161066 @default.
- W1569680763 cites W2073250481 @default.
- W1569680763 cites W2076489186 @default.
- W1569680763 cites W2078160318 @default.
- W1569680763 cites W2078637152 @default.
- W1569680763 cites W2079499766 @default.
- W1569680763 cites W2080152617 @default.
- W1569680763 cites W2083963451 @default.
- W1569680763 cites W2085064863 @default.
- W1569680763 cites W2085446376 @default.
- W1569680763 cites W2088218088 @default.
- W1569680763 cites W2089646867 @default.
- W1569680763 cites W2090474174 @default.
- W1569680763 cites W2090810672 @default.
- W1569680763 cites W2092790574 @default.
- W1569680763 cites W2094247207 @default.
- W1569680763 cites W2096101727 @default.
- W1569680763 cites W2099884205 @default.
- W1569680763 cites W2102101495 @default.
- W1569680763 cites W2103385168 @default.
- W1569680763 cites W2103590067 @default.
- W1569680763 cites W2109126550 @default.
- W1569680763 cites W2112093320 @default.
- W1569680763 cites W2117415893 @default.
- W1569680763 cites W2118093120 @default.
- W1569680763 cites W2122341536 @default.
- W1569680763 cites W2129625403 @default.
- W1569680763 cites W2150073376 @default.
- W1569680763 cites W2168976962 @default.
- W1569680763 cites W2039282950 @default.
- W1569680763 doi "https://doi.org/10.1016/s0074-7696(08)62454-7" @default.
- W1569680763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1555922" @default.
- W1569680763 hasPublicationYear "1992" @default.
- W1569680763 type Work @default.
- W1569680763 sameAs 1569680763 @default.
- W1569680763 citedByCount "49" @default.
- W1569680763 countsByYear W15696807632020 @default.
- W1569680763 countsByYear W15696807632023 @default.
- W1569680763 crossrefType "book-chapter" @default.
- W1569680763 hasAuthorship W1569680763A5012843007 @default.
- W1569680763 hasAuthorship W1569680763A5067688389 @default.
- W1569680763 hasConcept C104317684 @default.
- W1569680763 hasConcept C121608353 @default.
- W1569680763 hasConcept C127716648 @default.
- W1569680763 hasConcept C141231307 @default.
- W1569680763 hasConcept C142669718 @default.
- W1569680763 hasConcept C1491633281 @default.
- W1569680763 hasConcept C51785407 @default.