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• W1569685664 endingPage "7425" @default.
• W1569685664 startingPage "7416" @default.
• W1569685664 abstract "Abstract Like viruses, intracellular bacteria stimulate their host cells to produce type I IFNs (IFN-α and IFN-β). In our study, we investigated the signals and molecules relevant for the synthesis of and response to IFN by mouse macrophages infected with Listeria monocytogenes. We report that IFN-β is the critical immediate-early IFN made during infection, because the synthesis of all other type I IFN, expression of a subset of infection-induced genes, and the biological response to type I IFN was lost upon IFN-β deficiency. The induction of IFN-β mRNA and the IFN-β-dependent sensitization of macrophages to bacteria-induced death, in turn, was absolutely dependent upon the presence of the transcription factor IFN regulatory factor 3 (IRF3). IFN-β synthesis and signal transduction occurred in macrophages deficient for TLR or their adaptors MyD88, TRIF, or TRAM. Expression of Nod2, a candidate receptor for intracellular bacteria, increased during infection, but the protein was not required for Listeria-induced signal transduction to the Ifn-β gene. Based on our data, we propose that IRF3 is a convergence point for signals derived from structurally unrelated intracellular pathogens, and that L. monocytogenes stimulates a novel TLR- and Nod2-independent pathway to target IRF3 and the type I IFN genes." @default.
• W1569685664 created "2016-06-24" @default.
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• W1569685664 date "2004-12-15" @default.
• W1569685664 modified "2023-10-01" @default.
• W1569685664 title "IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism" @default.
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• W1569685664 cites W1519633296 @default.
• W1569685664 cites W1534699340 @default.
• W1569685664 cites W1549282362 @default.
• W1569685664 cites W1570229015 @default.
• W1569685664 cites W1646413467 @default.
• W1569685664 cites W1666331631 @default.
• W1569685664 cites W1964141567 @default.
• W1569685664 cites W1969072247 @default.
• W1569685664 cites W1969430178 @default.
• W1569685664 cites W1974623065 @default.
• W1569685664 cites W1975764372 @default.
• W1569685664 cites W1978437791 @default.
• W1569685664 cites W1980768668 @default.
• W1569685664 cites W1982637996 @default.
• W1569685664 cites W1989656760 @default.
• W1569685664 cites W1990122501 @default.
• W1569685664 cites W1994391392 @default.
• W1569685664 cites W1996120614 @default.
• W1569685664 cites W2001096201 @default.
• W1569685664 cites W2009761514 @default.
• W1569685664 cites W2015415445 @default.
• W1569685664 cites W2030611349 @default.
• W1569685664 cites W2031747611 @default.
• W1569685664 cites W2040024879 @default.
• W1569685664 cites W2042608016 @default.
• W1569685664 cites W2044335855 @default.
• W1569685664 cites W2045384882 @default.
• W1569685664 cites W2047850703 @default.
• W1569685664 cites W2049874360 @default.
• W1569685664 cites W2057809738 @default.
• W1569685664 cites W2058755167 @default.
• W1569685664 cites W2063273780 @default.
• W1569685664 cites W2068466303 @default.
• W1569685664 cites W2075583035 @default.
• W1569685664 cites W2076361525 @default.
• W1569685664 cites W2079357798 @default.
• W1569685664 cites W2082890018 @default.
• W1569685664 cites W2084460640 @default.
• W1569685664 cites W2086400782 @default.
• W1569685664 cites W2086607027 @default.
• W1569685664 cites W2087814657 @default.
• W1569685664 cites W2089077517 @default.
• W1569685664 cites W2092250990 @default.
• W1569685664 cites W2092289677 @default.
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• W1569685664 cites W2113757071 @default.
• W1569685664 cites W2116136184 @default.
• W1569685664 cites W2119910602 @default.
• W1569685664 cites W2122822209 @default.
• W1569685664 cites W2125309974 @default.
• W1569685664 cites W2126569085 @default.
• W1569685664 cites W2126735123 @default.
• W1569685664 cites W2130421043 @default.
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• W1569685664 doi "https://doi.org/10.4049/jimmunol.173.12.7416" @default.
• W1569685664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15585867" @default.
• W1569685664 hasPublicationYear "2004" @default.
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