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- W1569690226 abstract "The postnatal development of acetylcholinesterase (AChE) activity in the hippocampal formation of the developing rat brain, as demonstrated histochemically by the copper-thiocholine technique, serves as a marker for the ingrowing cholinergic afferent fibers. The discrete laminar pattern of staining characteristic of the adult hippocampal formation develops entirely after birth. Stain deposit is observable earliest (about 4 days after birth) at the septal end of the hippocampus. During the following week, AChE activity can be demonstrated in successively temporal segments until, about 11 days after birth, all parts of the hippocampal formation exhibit activity. Within each segment, the pattern of developing activity suggests association with three distinct fiber projections emanating from the fimbria, each with its own characteristic time of appearance and rate of growth: (1) a projection through stratum oriens of hippocampus regio inferior to stratum oriens of regio superior; (2) fibers which cross straum pyramidale of regio inferior, run in the suprapyramidal zone of that region and continue into the supra- and infragranular zones in the external leaf of the dentate gyrus; (3) a projection through stratum oriens of regio inferior which continues into the supra- and infragranular zones in the internal leaf of the dentate gyrus." @default.
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- W1569690226 date "1974-01-01" @default.
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- W1569690226 title "Development of cholinergic innervation in the hippocampal formation of the rat" @default.
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- W1569690226 doi "https://doi.org/10.1016/0012-1606(74)90196-1" @default.
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