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• W1569697157 abstract "Abstract Two forms of dipeptidyl peptidase IV (DPP) were purified from rat liver plasma membranes: a membrane form (mDPP) extracted with Triton X-100 and a soluble form (sDPP) prepared by treatment with papain. Apparent molecular masses of mDPP and sDPP were 109 and 105 kDa, respectively, when determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The NH2-terminal sequences of the two forms were found to be completely different from each other. For further information on the molecular structure, we constructed a lambda gt11 liver cDNA library and isolated two cDNA clones for DPP, lambda cDP37 and lambda cD5. The 3.5-kilobase cDNA insert of lambda cDP37 contains an open reading frame that encodes a 767-residue polypeptide with a calculated size of 88,107 Da, which is in reasonable agreement with that of DPP (87 kDa) immunoprecipitated from cell-free translation products. Eight potential N-linked glycosylation sites were found in the molecule, accounting for the difference in mass between the precursor and mature forms. Of particular interest is that the deduced NH2-terminal sequence with a characteristic signal peptide is completely identical to that determined for mDPP. In addition, the NH2-terminal sequence of sDPP is identified in the predicted sequence starting at the 35th position from the NH2 terminus. These results indicate that the signal peptide of DPP is not cleaved off during biosynthesis but functions as the membrane-anchoring domain even in the mature form. It is also found that the primary structure thus predicted has striking homology to that of gp 110, a bile canaliculus domain-specific membrane glycoprotein (Hong, W., and Doyle, D. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 7962-7966)." @default.
• W1569697157 created "2016-06-24" @default.
• W1569697157 creator A5056261551 @default.
• W1569697157 creator A5058208041 @default.
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• W1569697157 date "1989-02-01" @default.
• W1569697157 modified "2023-10-13" @default.
• W1569697157 title "Primary Structure of Rat Liver Dipeptidyl Peptidase IV Deduced from Its cDNA and Identification of the NH2-Terminal Signal Sequence as the Membrane-anchoring Domain" @default.
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• W1569697157 doi "https://doi.org/10.1016/s0021-9258(18)94108-6" @default.
• W1569697157 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2563382" @default.
• W1569697157 hasPublicationYear "1989" @default.
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