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• W1569698611 startingPage "67" @default.
• W1569698611 abstract "This chapter focuses on the genetic alterations of cyclins, cyclin dependent kinases (Cdk), and Cdk inhibitors in human cancer. Contemporary research into the molecular basis of cancer has two central tenets. The first is that cancer arises through alterations in the genetic make-up of the tumor cell. The second is that these changes are manifested in the breakdown of the processes that regulate cell growth and differentiation. In simplistic terms, cancer cells proliferate uncontrollably and fail to differentiate. The large numbers of tumors that show perturbations in the D cyclins themselves, their upstream regulators, or their downstream targets suggest that this pathway is extremely important in human cancer and holds great promise for therapeutic intervention. The conventional view of the cell division cycle is as a series of checkpoints or transitions at which certain criteria must be met before the cell proceeds to the next phase. The cyclin D1 gene, now given the locus designation CCNDI, maps to band q13 on the long arm of chromosome 11. The chapter also discusses the amplification of cyclin D1 in human tumors. When the gene for Cdk4 was located on chromosome 12q13, it was quickly realized that it too lies within a tumor-specific amplicon, which had been previously observed in human sarcomas of various types and in tumors of the central nervous system, particularly gliomas. There has been a great deal of interest in the cyclin-dependent kinase inhibitors that have been identified in mammalian cells. The chapter describes cyclin D1-p16-pRb pathway." @default.
• W1569698611 created "2016-06-24" @default.
• W1569698611 creator A5016742379 @default.
• W1569698611 creator A5051758709 @default.
• W1569698611 date "1996-01-01" @default.
• W1569698611 modified "2023-10-13" @default.
• W1569698611 title "Genetic Alterations of Cyclins, Cyclin-Dependent Kinases, and Cdk Inhibitors in Human Cancer" @default.
• W1569698611 cites W139568188 @default.
• W1569698611 cites W1498109352 @default.
• W1569698611 cites W1517159206 @default.
• W1569698611 cites W1525362852 @default.
• W1569698611 cites W1547849202 @default.
• W1569698611 cites W1560943589 @default.
• W1569698611 cites W1709607181 @default.
• W1569698611 cites W181471869 @default.
• W1569698611 cites W1851503105 @default.
• W1569698611 cites W1923636344 @default.
• W1569698611 cites W1963859780 @default.
• W1569698611 cites W1964947899 @default.
• W1569698611 cites W1968046362 @default.
• W1569698611 cites W1969846119 @default.
• W1569698611 cites W1970624224 @default.
• W1569698611 cites W1971512164 @default.
• W1569698611 cites W1973134510 @default.
• W1569698611 cites W1973277018 @default.
• W1569698611 cites W1977706798 @default.
• W1569698611 cites W1978313777 @default.
• W1569698611 cites W1979389942 @default.
• W1569698611 cites W1981035755 @default.
• W1569698611 cites W1982283757 @default.
• W1569698611 cites W1982336487 @default.
• W1569698611 cites W1982928787 @default.
• W1569698611 cites W1983348452 @default.
• W1569698611 cites W1983789135 @default.
• W1569698611 cites W1984379066 @default.
• W1569698611 cites W1985035051 @default.
• W1569698611 cites W1985745152 @default.
• W1569698611 cites W1989817991 @default.
• W1569698611 cites W1990291331 @default.
• W1569698611 cites W1990635332 @default.
• W1569698611 cites W1990856491 @default.
• W1569698611 cites W1991776950 @default.
• W1569698611 cites W1993659376 @default.
• W1569698611 cites W1994066190 @default.
• W1569698611 cites W1994082723 @default.
• W1569698611 cites W1996121905 @default.
• W1569698611 cites W1997073961 @default.
• W1569698611 cites W1997897487 @default.
• W1569698611 cites W2002594032 @default.
• W1569698611 cites W2003008937 @default.
• W1569698611 cites W2003907692 @default.
• W1569698611 cites W200461798 @default.
• W1569698611 cites W2005662944 @default.
• W1569698611 cites W2005677919 @default.
• W1569698611 cites W2005941837 @default.
• W1569698611 cites W2007255413 @default.
• W1569698611 cites W2008448206 @default.
• W1569698611 cites W2008728741 @default.
• W1569698611 cites W2009573109 @default.
• W1569698611 cites W2009967055 @default.
• W1569698611 cites W2010493387 @default.
• W1569698611 cites W2011301929 @default.
• W1569698611 cites W2012852725 @default.
• W1569698611 cites W2014296185 @default.
• W1569698611 cites W2015066175 @default.
• W1569698611 cites W2015519364 @default.
• W1569698611 cites W2016136975 @default.
• W1569698611 cites W2016952896 @default.
• W1569698611 cites W2017689200 @default.
• W1569698611 cites W2018852005 @default.
• W1569698611 cites W2020946972 @default.
• W1569698611 cites W2021666874 @default.
• W1569698611 cites W2024763413 @default.
• W1569698611 cites W2026221599 @default.
• W1569698611 cites W2026470201 @default.
• W1569698611 cites W2027558915 @default.
• W1569698611 cites W2027744191 @default.
• W1569698611 cites W2028083697 @default.
• W1569698611 cites W2029956867 @default.
• W1569698611 cites W2032236714 @default.
• W1569698611 cites W2032510122 @default.
• W1569698611 cites W2032911567 @default.
• W1569698611 cites W2033156691 @default.
• W1569698611 cites W2034708422 @default.
• W1569698611 cites W2035882662 @default.
• W1569698611 cites W2036696412 @default.
• W1569698611 cites W2036803073 @default.
• W1569698611 cites W2037903080 @default.
• W1569698611 cites W2039263836 @default.
• W1569698611 cites W2039781495 @default.
• W1569698611 cites W2040189858 @default.
• W1569698611 cites W2041525026 @default.
• W1569698611 cites W2041792131 @default.
• W1569698611 cites W2044285220 @default.
• W1569698611 cites W2045920572 @default.
• W1569698611 cites W2046577405 @default.
• W1569698611 cites W2048721919 @default.
• W1569698611 cites W2049296174 @default.

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