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• W1569709067 abstract "SUMMARY Background Small bowel mucosal injury associated with non‐selective non‐steroidal anti‐inflammatory drugs is being increasingly recognized. Aim To evaluate the incidence of small bowel injury in healthy subjects receiving celecoxib or ibuprofen plus omeprazole using video capsule endoscopy (VCE). Methods Subjects with normal baseline VCE were randomly assigned to receive celecoxib 200 mg b.d., ibuprofen 800 mg t.d.s. plus omeprazole 20 mg o.d. or placebo for 2 weeks. The primary end point was mean number of small bowel mucosal breaks per subject. Secondary end points included correlation of faecal calprotectin levels with the primary outcome. Results After treatment, the mean number of small bowel mucosal breaks per subject and the percentage of subjects with mucosal breaks were 0.7/25.9% for ibuprofen/omeprazole compared with 0.2/6.4% for celecoxib and 0.1/7.1% placebo (both comparisons P < 0.001). There were no significant differences between celecoxib and placebo in any measure. Mean increases in faecal calprotectin levels were higher in subjects receiving ibuprofen/omeprazole compared with celecoxib ( P < 0.001), but no correlation was determined between these levels and small bowel mucosal breaks. Conclusions Among healthy subjects with no baseline endoscopic lesions, celecoxib was associated with significantly fewer small bowel mucosal breaks than ibuprofen/omeprazole as assessed by VCE." @default.
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• W1569709067 date "2007-03-12" @default.
• W1569709067 modified "2023-10-15" @default.
• W1569709067 title "Small bowel mucosal injury is reduced in healthy subjects treated with celecoxib compared with ibuprofen plus omeprazole, as assessed by video capsule endoscopy" @default.
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• W1569709067 doi "https://doi.org/10.1111/j.1365-2036.2007.03312.x" @default.
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