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• W1569709152 abstract "Drug addiction is a brain disorder that has negative consequences for individuals and society. Addictions are chronic relapsing diseases of the brain that are caused by direct drug-induced effects and persevering neuroadaptations at the epigenetic, neuropeptide and neurotransmitter levels. Because the dopaminergic system has a significant role in drug abuse, the purpose of this study was to analyze the methylation and expression profile of brain-derived neurotrophic factor (BDNF) and dopamine transporter (DAT1) genes in individuals with drug addiction.BDNF and DAT1 promoter methylation were investigated with a methylation-specific polymerase chain reaction (PCR) technique in blood samples from 75 individuals with drug addiction and 65 healthy controls. The expression levels of BDNF and DAT1 were assessed in 12 mRNA samples from the blood of patients and compared to the samples of healthy controls (n = 12) with real-time quantitative reverse transcription PCR.No significant differences were found in the methylation of BDNF and DAT1 between patients and controls, but the relative levels of expression of BDNF and DAT1 mRNA differed significantly in the patients compared to controls (p < 0.0001).These results showed that the methylation status of the BDNF and DAT1 genes had no significant function in the processes of drug addiction." @default.
• W1569709152 created "2016-06-24" @default.
• W1569709152 creator A5044955064 @default.
• W1569709152 creator A5053898372 @default.
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• W1569709152 date "2015-01-01" @default.
• W1569709152 modified "2023-09-27" @default.
• W1569709152 title "Promoter Methylation and <b><i>BDNF</i></b> and <b><i>DAT1</i></b> Gene Expression Profiles in Patients with Drug Addiction" @default.
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• W1569709152 doi "https://doi.org/10.1159/000430465" @default.
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