FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569732670> ?p ?o ?g. }

• W1569732670 endingPage "253" @default.
• W1569732670 startingPage "247" @default.
• W1569732670 abstract "Glycogen synthase kinase-3 beta (GSK-3beta) is involved in many cellular processes, such as metabolism, apoptosis, differentiation and proliferation. Insulin-like growth factor-1 (IGF-1), which is well known to have a hypertrophic effect on cardiomyocytes, inactivates (phosphorylates) GSK-3beta in some cell types. The role of GSK-3beta in cardiomyocytes as a negative regulator of cardiac hypertrophy has been recently reported and the present study investigated the role of GSK-3beta in the cardiac hypertrophy of cultivated neonatal rat cardiomyocytes induced by IGF-1.First, the IGF-1 induced signal transduction leading to GSK-3beta in neonatal rat cardiomyocytes was examined. The phosphatidylinositol (PI) 3-kinase/Akt/GSK-3 beta signaling induced by IGF-1 was investigated using inhibitors of PI 3-kinase and Ad AktAA, a dominant negative form of Akt. Furthermore, using Ad MEK DN, a dominant negative form of MEK, it was found that MEK negatively regulates Akt phosphorylation upon IGF-1 stimulation. Next, it was examined whether GSK-3beta acts as a negative regulator in the cardiac hypertrophy induced by IGF-1. Sustained stimulation by IGF-1 caused cardiac hypertrophy in protein synthesis and cellular morphology, and overexpression of unphosphorylatable GSK-3beta (Ad GSK-3beta S9A) repressed these hypertrophic effects of IGF-1.GSK-3beta may play an important role as a negative regulator of cardiac hypertrophy induced by IGF-1." @default.
• W1569732670 created "2016-06-24" @default.
• W1569732670 creator A5003043319 @default.
• W1569732670 creator A5024706169 @default.
• W1569732670 creator A5035360190 @default.
• W1569732670 creator A5035596282 @default.
• W1569732670 creator A5039208853 @default.
• W1569732670 creator A5050600382 @default.
• W1569732670 creator A5054125226 @default.
• W1569732670 creator A5082647122 @default.
• W1569732670 creator A5087872679 @default.
• W1569732670 date "2004-01-01" @default.
• W1569732670 modified "2023-10-06" @default.
• W1569732670 title "Glycogen Synthase Kinase-3.BETA. is Involved in the Process of Myocardial Hypertrophy Stimulated by Insulin-Like Growth Factor-1" @default.
• W1569732670 cites W1521905573 @default.
• W1569732670 cites W1531537331 @default.
• W1569732670 cites W1565234800 @default.
• W1569732670 cites W1568017411 @default.
• W1569732670 cites W1657298386 @default.
• W1569732670 cites W167818004 @default.
• W1569732670 cites W1791035026 @default.
• W1569732670 cites W1875111347 @default.
• W1569732670 cites W1908612571 @default.
• W1569732670 cites W1968547385 @default.
• W1569732670 cites W1973949704 @default.
• W1569732670 cites W1984572394 @default.
• W1569732670 cites W1992393431 @default.
• W1569732670 cites W2001333805 @default.
• W1569732670 cites W2004549688 @default.
• W1569732670 cites W2008421466 @default.
• W1569732670 cites W2012083843 @default.
• W1569732670 cites W2012356167 @default.
• W1569732670 cites W2014891807 @default.
• W1569732670 cites W2024306318 @default.
• W1569732670 cites W2038073573 @default.
• W1569732670 cites W2051379969 @default.
• W1569732670 cites W2053265248 @default.
• W1569732670 cites W2058138221 @default.
• W1569732670 cites W2062748498 @default.
• W1569732670 cites W2067837318 @default.
• W1569732670 cites W2069813140 @default.
• W1569732670 cites W2070002301 @default.
• W1569732670 cites W2074187803 @default.
• W1569732670 cites W2075907691 @default.
• W1569732670 cites W2080518961 @default.
• W1569732670 cites W2082387343 @default.
• W1569732670 cites W2086449586 @default.
• W1569732670 cites W2094138142 @default.
• W1569732670 cites W2097767970 @default.
• W1569732670 cites W2105014609 @default.
• W1569732670 cites W2115207474 @default.
• W1569732670 cites W2117774225 @default.
• W1569732670 cites W2120967386 @default.
• W1569732670 cites W2122709827 @default.
• W1569732670 cites W2124432707 @default.
• W1569732670 cites W2140608810 @default.
• W1569732670 cites W2150200572 @default.
• W1569732670 cites W2156433522 @default.
• W1569732670 cites W2166748152 @default.
• W1569732670 cites W2171908036 @default.
• W1569732670 cites W2334499091 @default.
• W1569732670 doi "https://doi.org/10.1253/circj.68.247" @default.
• W1569732670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14993781" @default.
• W1569732670 hasPublicationYear "2004" @default.
• W1569732670 type Work @default.
• W1569732670 sameAs 1569732670 @default.
• W1569732670 citedByCount "22" @default.
• W1569732670 countsByYear W15697326702012 @default.
• W1569732670 countsByYear W15697326702014 @default.
• W1569732670 countsByYear W15697326702015 @default.
• W1569732670 countsByYear W15697326702016 @default.
• W1569732670 countsByYear W15697326702017 @default.
• W1569732670 countsByYear W15697326702021 @default.
• W1569732670 countsByYear W15697326702023 @default.
• W1569732670 crossrefType "journal-article" @default.
• W1569732670 hasAuthorship W1569732670A5003043319 @default.
• W1569732670 hasAuthorship W1569732670A5024706169 @default.
• W1569732670 hasAuthorship W1569732670A5035360190 @default.
• W1569732670 hasAuthorship W1569732670A5035596282 @default.
• W1569732670 hasAuthorship W1569732670A5039208853 @default.
• W1569732670 hasAuthorship W1569732670A5050600382 @default.
• W1569732670 hasAuthorship W1569732670A5054125226 @default.
• W1569732670 hasAuthorship W1569732670A5082647122 @default.
• W1569732670 hasAuthorship W1569732670A5087872679 @default.
• W1569732670 hasBestOaLocation W15697326701 @default.
• W1569732670 hasConcept C104629339 @default.
• W1569732670 hasConcept C11960822 @default.
• W1569732670 hasConcept C126322002 @default.
• W1569732670 hasConcept C134018914 @default.
• W1569732670 hasConcept C167414201 @default.
• W1569732670 hasConcept C170493617 @default.
• W1569732670 hasConcept C182996813 @default.
• W1569732670 hasConcept C184235292 @default.
• W1569732670 hasConcept C185592680 @default.
• W1569732670 hasConcept C192118531 @default.
• W1569732670 hasConcept C2775960820 @default.
• W1569732670 hasConcept C2777499176 @default.
• W1569732670 hasConcept C2780689927 @default.

• next