FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569741533> ?p ?o ?g. }

• W1569741533 endingPage "22472" @default.
• W1569741533 startingPage "22467" @default.
• W1569741533 abstract "Insulin-like growth factor (IGF)-binding proteins (IGFBPs) either inhibit or enhance IGF-stimulated cellular effects. While inhibition occurs by sequestration of IGF from cell-surface receptors, the exact mechanism of IGF-enhancement remains undefined. Human osteoblast-like bone cells in culture secrete several IGF-binding proteins, one of which we have previously identified as IGFBP-5. In this study we purified a 23-kDa IGFBP-5 from cultures of human osteoblast-like cells using ligand affinity chromatography and reversed-phase high performance liquid chromatography and tested its bioactivity in serum-free cultures of normal mouse osteoblast-like cells. Binding studies with radioiodinated IGF showed similar and relatively low affinities for IGF-I and IGF-II consistent with a carboxyl truncated IGF-binding protein. Mitogenic assays demonstrated that the binding protein, when coincubated with IGF-I or -II, enhanced mitogenesis. This enhancement was unique from other binding proteins in not requiring a preincubation period or serum co-factors. Furthermore, the osteoblast-derived IGFBP-5 stimulated mitogenesis in the absence of exogenous or endogenous IGF. Using radioiodinated IGFBP-5 we found that the binding protein could associate with the osteoblast surface, an effect which did not require IGF nor an interaction with IGF receptors. We suggest that osteoblast-derived IGFBP-5 may stimulate osteoblast mitogenesis in at least two ways, by association with IGF and by a second pathway that is independent of IGF receptor activation." @default.
• W1569741533 created "2016-06-24" @default.
• W1569741533 creator A5036001696 @default.
• W1569741533 creator A5087076023 @default.
• W1569741533 date "1992-11-01" @default.
• W1569741533 modified "2023-10-17" @default.
• W1569741533 title "Human osteoblast-derived insulin-like growth factor (IGF) binding protein-5 stimulates osteoblast mitogenesis and potentiates IGF action." @default.
• W1569741533 cites W1483353862 @default.
• W1569741533 cites W1507411141 @default.
• W1569741533 cites W1511750039 @default.
• W1569741533 cites W1547915919 @default.
• W1569741533 cites W1571404318 @default.
• W1569741533 cites W1602528313 @default.
• W1569741533 cites W1605635614 @default.
• W1569741533 cites W1911366696 @default.
• W1569741533 cites W1959209906 @default.
• W1569741533 cites W1963533733 @default.
• W1569741533 cites W1964203795 @default.
• W1569741533 cites W1967709376 @default.
• W1569741533 cites W1968506930 @default.
• W1569741533 cites W1975228316 @default.
• W1569741533 cites W1975949772 @default.
• W1569741533 cites W1980186633 @default.
• W1569741533 cites W1981791036 @default.
• W1569741533 cites W1985220842 @default.
• W1569741533 cites W1990439069 @default.
• W1569741533 cites W1992668278 @default.
• W1569741533 cites W1997409229 @default.
• W1569741533 cites W1997620423 @default.
• W1569741533 cites W1999561771 @default.
• W1569741533 cites W1999582611 @default.
• W1569741533 cites W2001229549 @default.
• W1569741533 cites W2001908070 @default.
• W1569741533 cites W2003016121 @default.
• W1569741533 cites W2014059985 @default.
• W1569741533 cites W2014510338 @default.
• W1569741533 cites W2016839558 @default.
• W1569741533 cites W2017309664 @default.
• W1569741533 cites W2018005226 @default.
• W1569741533 cites W2018723236 @default.
• W1569741533 cites W2023205840 @default.
• W1569741533 cites W2023293227 @default.
• W1569741533 cites W2025831864 @default.
• W1569741533 cites W2029231027 @default.
• W1569741533 cites W2034816153 @default.
• W1569741533 cites W2043034285 @default.
• W1569741533 cites W2043576320 @default.
• W1569741533 cites W2045835452 @default.
• W1569741533 cites W2048627616 @default.
• W1569741533 cites W2056310569 @default.
• W1569741533 cites W2057200679 @default.
• W1569741533 cites W2058170465 @default.
• W1569741533 cites W2067928197 @default.
• W1569741533 cites W2071757792 @default.
• W1569741533 cites W2074747674 @default.
• W1569741533 cites W2075919355 @default.
• W1569741533 cites W2080572028 @default.
• W1569741533 cites W2081075932 @default.
• W1569741533 cites W2084796745 @default.
• W1569741533 cites W2090099477 @default.
• W1569741533 cites W2097477185 @default.
• W1569741533 cites W2111666458 @default.
• W1569741533 cites W2128683464 @default.
• W1569741533 doi "https://doi.org/10.1016/s0021-9258(18)41695-x" @default.
• W1569741533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1385400" @default.
• W1569741533 hasPublicationYear "1992" @default.
• W1569741533 type Work @default.
• W1569741533 sameAs 1569741533 @default.
• W1569741533 citedByCount "316" @default.
• W1569741533 countsByYear W15697415332012 @default.
• W1569741533 countsByYear W15697415332013 @default.
• W1569741533 countsByYear W15697415332014 @default.
• W1569741533 countsByYear W15697415332015 @default.
• W1569741533 countsByYear W15697415332016 @default.
• W1569741533 countsByYear W15697415332017 @default.
• W1569741533 countsByYear W15697415332018 @default.
• W1569741533 countsByYear W15697415332019 @default.
• W1569741533 countsByYear W15697415332020 @default.
• W1569741533 countsByYear W15697415332021 @default.
• W1569741533 countsByYear W15697415332022 @default.
• W1569741533 countsByYear W15697415332023 @default.
• W1569741533 crossrefType "journal-article" @default.
• W1569741533 hasAuthorship W1569741533A5036001696 @default.
• W1569741533 hasAuthorship W1569741533A5087076023 @default.
• W1569741533 hasBestOaLocation W15697415331 @default.
• W1569741533 hasConcept C126322002 @default.
• W1569741533 hasConcept C134018914 @default.
• W1569741533 hasConcept C170493617 @default.
• W1569741533 hasConcept C185592680 @default.
• W1569741533 hasConcept C202751555 @default.
• W1569741533 hasConcept C2775960820 @default.
• W1569741533 hasConcept C2778260815 @default.
• W1569741533 hasConcept C2779306644 @default.
• W1569741533 hasConcept C2780689927 @default.
• W1569741533 hasConcept C55493867 @default.
• W1569741533 hasConcept C71924100 @default.
• W1569741533 hasConcept C86803240 @default.
• W1569741533 hasConcept C95444343 @default.

• next