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- W1569744027 abstract "Genetic recombination is a critical cellular process that promotes evolutionary diversity, facilitates DNA repair and underpins genome duplication. It entails the reciprocal exchange of single strands between homologous DNA duplexes to form a four-way branched intermediate commonly referred to as the Holliday junction. DNA molecules interlinked in this way have to be separated in order to allow normal chromosome transmission at cell division. This resolution reaction is mediated by structure-specific endonucleases that catalyse dual-strand incision across the point of strand cross-over. Holliday junctions can also arise at stalled replication forks by reversing the direction of fork progression and annealing of nascent strands. Resolution of junctions in this instance generates a DNA break and thus serves to initiate rather than terminate recombination. Junction resolvases are generally small, homodimeric endonucleases with a high specificity for branched DNA. They use a metal-binding pocket to co-ordinate an activated water molecule for phosphodiester bond hydrolysis. In addition, most junction endonucleases modulate the structure of the junction upon binding, and some display a preference for cleavage at specific nucleotide target sequences. Holliday junction resolvases with distinct properties have been characterized from bacteriophages (T4 endo VII, T7 endo I, RusA and Rap), Bacteria (RuvC), Archaea (Hjc and Hje), yeast (CCE1) and poxviruses (A22R). Recent studies have brought about a reappraisal of the origins of junction-specific endonucleases with the discovery that RuvC, CCE1 and A22R share a common catalytic core." @default.
- W1569744027 created "2016-06-24" @default.
- W1569744027 creator A5038898027 @default.
- W1569744027 date "2001-12-21" @default.
- W1569744027 modified "2023-09-27" @default.
- W1569744027 title "The X philes: structure-specific endonucleases that resolve Holliday junctions" @default.
- W1569744027 cites W1491384344 @default.
- W1569744027 cites W1499339234 @default.
- W1569744027 cites W1530697726 @default.
- W1569744027 cites W1553481351 @default.
- W1569744027 cites W1566671679 @default.
- W1569744027 cites W1590546489 @default.
- W1569744027 cites W1595811992 @default.
- W1569744027 cites W1896186530 @default.
- W1569744027 cites W1966305880 @default.
- W1569744027 cites W1972852754 @default.
- W1569744027 cites W1974101462 @default.
- W1569744027 cites W1975384668 @default.
- W1569744027 cites W1977912434 @default.
- W1569744027 cites W1978202700 @default.
- W1569744027 cites W1978551146 @default.
- W1569744027 cites W1984085906 @default.
- W1569744027 cites W1985052477 @default.
- W1569744027 cites W1986398477 @default.
- W1569744027 cites W1989624089 @default.
- W1569744027 cites W1990226790 @default.
- W1569744027 cites W1993369437 @default.
- W1569744027 cites W1997607527 @default.
- W1569744027 cites W1998641591 @default.
- W1569744027 cites W1999659932 @default.
- W1569744027 cites W1999673205 @default.
- W1569744027 cites W1999735756 @default.
- W1569744027 cites W2006212265 @default.
- W1569744027 cites W2008577722 @default.
- W1569744027 cites W2009463705 @default.
- W1569744027 cites W2011700794 @default.
- W1569744027 cites W2014673973 @default.
- W1569744027 cites W2015968422 @default.
- W1569744027 cites W2016881508 @default.
- W1569744027 cites W2018858256 @default.
- W1569744027 cites W2020558769 @default.
- W1569744027 cites W2020715293 @default.
- W1569744027 cites W2027748565 @default.
- W1569744027 cites W2027820521 @default.
- W1569744027 cites W2029887349 @default.
- W1569744027 cites W2030582354 @default.
- W1569744027 cites W2039646812 @default.
- W1569744027 cites W2039764581 @default.
- W1569744027 cites W2047313081 @default.
- W1569744027 cites W2048680704 @default.
- W1569744027 cites W2057201443 @default.
- W1569744027 cites W2064786841 @default.
- W1569744027 cites W2065667431 @default.
- W1569744027 cites W2066218908 @default.
- W1569744027 cites W2066544743 @default.
- W1569744027 cites W2067944827 @default.
- W1569744027 cites W2074033471 @default.
- W1569744027 cites W2074203977 @default.
- W1569744027 cites W2075312339 @default.
- W1569744027 cites W2076430343 @default.
- W1569744027 cites W2077940170 @default.
- W1569744027 cites W2078983417 @default.
- W1569744027 cites W2092073545 @default.
- W1569744027 cites W2094929824 @default.
- W1569744027 cites W2098110766 @default.
- W1569744027 cites W2110977400 @default.
- W1569744027 cites W2122531070 @default.
- W1569744027 cites W2135089493 @default.
- W1569744027 cites W2136807851 @default.
- W1569744027 cites W2140204465 @default.
- W1569744027 cites W2152533207 @default.
- W1569744027 cites W2156971581 @default.
- W1569744027 cites W2159075866 @default.
- W1569744027 cites W2160393299 @default.
- W1569744027 cites W2165371679 @default.
- W1569744027 cites W2170075515 @default.
- W1569744027 cites W322099565 @default.
- W1569744027 cites W2033913257 @default.
- W1569744027 doi "https://doi.org/10.1046/j.1365-2958.2001.02284.x" @default.
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