FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569746696> ?p ?o ?g. }

• W1569746696 endingPage "6944" @default.
• W1569746696 startingPage "6937" @default.
• W1569746696 abstract "Expression of the human immunodeficiency virus type 1 (HIV-1) is strongly activated by Tat. The proper action of Tat requires three elements: TATAA, TAR, and upstream motifs in the HIV-1 long terminal repeat. We show here that the correct spatial arrangement among Tat, Sp1, and TATAA crucially influences HIV expression. Under conditions in which basal promoter activity is unperturbed, distancing Sp1 from TATAA markedly affected Tat trans activation. An increase in the Sp1-TATAA distance from 18 to 101 nucleotides (depending on the inserted sequence) rendered HIV-1 either partially or wholly replication defective. This critical dependence on spacing suggests that Tat-, Sp1-, and TATAA-binding factors must correctly contact each other for optimal expression and replication of HIV-1." @default.
• W1569746696 created "2016-06-24" @default.
• W1569746696 creator A5072656839 @default.
• W1569746696 creator A5080524336 @default.
• W1569746696 date "1993-12-01" @default.
• W1569746696 modified "2023-09-25" @default.
• W1569746696 title "Increased spacing between Sp1 and TATAA renders human immunodeficiency virus type 1 replication defective: implication for Tat function" @default.
• W1569746696 cites W14142522 @default.
• W1569746696 cites W1539157784 @default.
• W1569746696 cites W1564126799 @default.
• W1569746696 cites W1605861738 @default.
• W1569746696 cites W1613477799 @default.
• W1569746696 cites W1659719610 @default.
• W1569746696 cites W174335069 @default.
• W1569746696 cites W1862719997 @default.
• W1569746696 cites W1928589437 @default.
• W1569746696 cites W1936470344 @default.
• W1569746696 cites W1953437662 @default.
• W1569746696 cites W1965372133 @default.
• W1569746696 cites W1966425882 @default.
• W1569746696 cites W1978539107 @default.
• W1569746696 cites W1983546572 @default.
• W1569746696 cites W2002479050 @default.
• W1569746696 cites W2011460282 @default.
• W1569746696 cites W2016328587 @default.
• W1569746696 cites W2021393380 @default.
• W1569746696 cites W2023262811 @default.
• W1569746696 cites W2028440457 @default.
• W1569746696 cites W2028706937 @default.
• W1569746696 cites W2033217413 @default.
• W1569746696 cites W2035516686 @default.
• W1569746696 cites W2065114401 @default.
• W1569746696 cites W2072528655 @default.
• W1569746696 cites W2076941373 @default.
• W1569746696 cites W2077708687 @default.
• W1569746696 cites W2078406153 @default.
• W1569746696 cites W2079557259 @default.
• W1569746696 cites W2080835064 @default.
• W1569746696 cites W2088493593 @default.
• W1569746696 cites W2090084965 @default.
• W1569746696 cites W2093428365 @default.
• W1569746696 cites W2095839679 @default.
• W1569746696 cites W2111817213 @default.
• W1569746696 cites W2136203932 @default.
• W1569746696 cites W2139018692 @default.
• W1569746696 cites W2144206181 @default.
• W1569746696 cites W2144700097 @default.
• W1569746696 cites W2180476901 @default.
• W1569746696 doi "https://doi.org/10.1128/jvi.67.12.6937-6944.1993" @default.
• W1569746696 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/238151" @default.
• W1569746696 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8230415" @default.
• W1569746696 hasPublicationYear "1993" @default.
• W1569746696 type Work @default.
• W1569746696 sameAs 1569746696 @default.
• W1569746696 citedByCount "47" @default.
• W1569746696 countsByYear W15697466962012 @default.
• W1569746696 countsByYear W15697466962018 @default.
• W1569746696 countsByYear W15697466962019 @default.
• W1569746696 crossrefType "journal-article" @default.
• W1569746696 hasAuthorship W1569746696A5072656839 @default.
• W1569746696 hasAuthorship W1569746696A5080524336 @default.
• W1569746696 hasBestOaLocation W15697466961 @default.
• W1569746696 hasConcept C104317684 @default.
• W1569746696 hasConcept C140704245 @default.
• W1569746696 hasConcept C153911025 @default.
• W1569746696 hasConcept C159047783 @default.
• W1569746696 hasConcept C2522874641 @default.
• W1569746696 hasConcept C54355233 @default.
• W1569746696 hasConcept C67705224 @default.
• W1569746696 hasConcept C86803240 @default.
• W1569746696 hasConceptScore W1569746696C104317684 @default.
• W1569746696 hasConceptScore W1569746696C140704245 @default.
• W1569746696 hasConceptScore W1569746696C153911025 @default.
• W1569746696 hasConceptScore W1569746696C159047783 @default.
• W1569746696 hasConceptScore W1569746696C2522874641 @default.
• W1569746696 hasConceptScore W1569746696C54355233 @default.
• W1569746696 hasConceptScore W1569746696C67705224 @default.
• W1569746696 hasConceptScore W1569746696C86803240 @default.
• W1569746696 hasIssue "12" @default.
• W1569746696 hasLocation W15697466961 @default.
• W1569746696 hasLocation W15697466962 @default.
• W1569746696 hasLocation W15697466963 @default.
• W1569746696 hasLocation W15697466964 @default.
• W1569746696 hasOpenAccess W1569746696 @default.
• W1569746696 hasPrimaryLocation W15697466961 @default.
• W1569746696 hasRelatedWork W1608862421 @default.
• W1569746696 hasRelatedWork W1825162875 @default.
• W1569746696 hasRelatedWork W2010478346 @default.
• W1569746696 hasRelatedWork W2086632997 @default.
• W1569746696 hasRelatedWork W2142935324 @default.
• W1569746696 hasRelatedWork W2147145791 @default.
• W1569746696 hasRelatedWork W2170219552 @default.
• W1569746696 hasRelatedWork W2406270448 @default.
• W1569746696 hasRelatedWork W2613621187 @default.
• W1569746696 hasRelatedWork W3165029026 @default.
• W1569746696 hasVolume "67" @default.
• W1569746696 isParatext "false" @default.
• W1569746696 isRetracted "false" @default.

• next