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• W1569761958 abstract "The liver is renowned for its strong, robust regenerative capacity, employing different modes of regeneration according to type and extent of injury. The process of compensatory hypertrophy of the liver upon partial hepatectomy has been standing as a classical model for studying organ regeneration in mammals and a subject of exhaustive analyses. Meanwhile, in view of the physiological relevance for many of the human liver pathologies induced upon toxic insults or hepatitis, other injury models have recently drawn increasing attention. In those damaged livers where hepatocyte proliferation is compromised, adult liver stem/progenitor cells (LPCs) are activated and differentiate to hepatocytes and cholangiocytes, leading to functional recovery of the organ. Here, we summarize and discuss recent findings on the mechanisms underlying the regeneration process of the liver. Whereas the primary focus of this article is on those related to LPC-mediated regeneration, we also introduce topics on compensatory hypertrophy, where application of new technologies and molecular genetics approaches in mice has gained a paradigm shift. Identification of various markers for LPC populations has expedited their characterization and enabled us to examine their differentiation potential in vivo using genetic lineage-tracing approaches. Comprehensive studies regarding intercellular signaling pathways and their modes of action have succeeded in elucidating novel frameworks for the LPC-niche interaction functioning in the regenerating liver. Conclusion: Advancing our understanding of the cellular and molecular mechanisms for liver regeneration should provide a basis for developing therapeutic strategies to treat patients with liver disease. (Hepatology 2014;59:1617-1626)" @default.
• W1569761958 created "2016-06-24" @default.
• W1569761958 creator A5016969792 @default.
• W1569761958 creator A5069121285 @default.
• W1569761958 date "2014-02-14" @default.
• W1569761958 modified "2023-10-14" @default.
• W1569761958 title "Liver regeneration by stem/progenitor cells" @default.
• W1569761958 cites W1533427944 @default.
• W1569761958 cites W176224146 @default.
• W1569761958 cites W1849852137 @default.
• W1569761958 cites W1966131296 @default.
• W1569761958 cites W1972126834 @default.
• W1569761958 cites W1982934598 @default.
• W1569761958 cites W1983942535 @default.
• W1569761958 cites W1984188920 @default.
• W1569761958 cites W1985109279 @default.
• W1569761958 cites W1990765314 @default.
• W1569761958 cites W1992365936 @default.
• W1569761958 cites W1998666537 @default.
• W1569761958 cites W2003215294 @default.
• W1569761958 cites W2005176562 @default.
• W1569761958 cites W2007042731 @default.
• W1569761958 cites W2007832228 @default.
• W1569761958 cites W2008285918 @default.
• W1569761958 cites W2011605269 @default.
• W1569761958 cites W2011862114 @default.
• W1569761958 cites W2011941999 @default.
• W1569761958 cites W2013051684 @default.
• W1569761958 cites W2018629625 @default.
• W1569761958 cites W2022425899 @default.
• W1569761958 cites W2025966264 @default.
• W1569761958 cites W2032537363 @default.
• W1569761958 cites W2033120556 @default.
• W1569761958 cites W2034098793 @default.
• W1569761958 cites W2037902063 @default.
• W1569761958 cites W2038120192 @default.
• W1569761958 cites W2043587965 @default.
• W1569761958 cites W2044468028 @default.
• W1569761958 cites W2045707643 @default.
• W1569761958 cites W2046104499 @default.
• W1569761958 cites W2046195617 @default.
• W1569761958 cites W2050271479 @default.
• W1569761958 cites W2052563864 @default.
• W1569761958 cites W2053820570 @default.
• W1569761958 cites W2055074097 @default.
• W1569761958 cites W2056510085 @default.
• W1569761958 cites W2057127002 @default.
• W1569761958 cites W2068278990 @default.
• W1569761958 cites W2068322917 @default.
• W1569761958 cites W2069250799 @default.
• W1569761958 cites W2073613428 @default.
• W1569761958 cites W2074966846 @default.
• W1569761958 cites W2081898172 @default.
• W1569761958 cites W2084074847 @default.
• W1569761958 cites W2089140170 @default.
• W1569761958 cites W2092964316 @default.
• W1569761958 cites W2093994858 @default.
• W1569761958 cites W2094243584 @default.
• W1569761958 cites W2100793148 @default.
• W1569761958 cites W2101974070 @default.
• W1569761958 cites W2102869463 @default.
• W1569761958 cites W2103385665 @default.
• W1569761958 cites W2105031631 @default.
• W1569761958 cites W2111710032 @default.
• W1569761958 cites W2122114596 @default.
• W1569761958 cites W2123128269 @default.
• W1569761958 cites W2124590862 @default.
• W1569761958 cites W2124782385 @default.
• W1569761958 cites W2127320439 @default.
• W1569761958 cites W2133246987 @default.
• W1569761958 cites W2133385241 @default.
• W1569761958 cites W2133860937 @default.
• W1569761958 cites W2135149891 @default.
• W1569761958 cites W2141006081 @default.
• W1569761958 cites W2150187570 @default.
• W1569761958 cites W2150640796 @default.
• W1569761958 cites W2155189607 @default.
• W1569761958 cites W2163478957 @default.
• W1569761958 cites W2164721923 @default.
• W1569761958 cites W2166192049 @default.
• W1569761958 cites W2167943387 @default.
• W1569761958 cites W2443195828 @default.
• W1569761958 cites W4210995852 @default.
• W1569761958 cites W4211173486 @default.
• W1569761958 cites W4254164242 @default.
• W1569761958 cites W89320799 @default.
• W1569761958 doi "https://doi.org/10.1002/hep.26753" @default.
• W1569761958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24115180" @default.
• W1569761958 hasPublicationYear "2014" @default.
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