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- W1569768208 abstract "The study objective: to assess the influence of alfacalcidol treatment on risk of falling in real clinical practice. Methods. Prospective cohort study included 46 postmenopausal women aged from 52 to 78, who had high risk of falling, low bone mineral density, glomerular filtration rate from 65 to 30 ml/min, signed informed consent and were naïve to calcium, vitamin D and antiresorptive agents. All patients have participated in Osteoporosis Patients School Classes, received prescriptions for daily 1 mcg alfacalcidol and approved recommendations on lifestyle modifications including diet, exercises and movement patterns. Individual risk of falling was assessed with the help of Guralnik Short Physical Performance Battery Score. Results. There were no new cases of falling and fractures in the cohort during 12 months. During the study period 28 women showed compliance to alfacalcidol 80% or more (group 1), in 15 patients compliance was less than 80% (group 2) and 3 women decided to quit the study. Only group 1 demonstrated significant physical function changes for the better while there were no significant changes in group 2. Conclusion. In a group of postmenopausal women with high risk of falling and fractures, significant positive changes in lower extremity performance and balance tests were registered only in women with 80% or higher compliance to alfacalcidol consumption." @default.
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- W1569768208 date "2010-08-15" @default.
- W1569768208 modified "2023-09-23" @default.
- W1569768208 title "Otsenka riska padeniy zhenshchin s postmenopauzal'nymosteoporozom, poluchayushchikh al'fakal'tsidol" @default.
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- W1569768208 doi "https://doi.org/10.14341/osteo2010215-17" @default.
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